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A Randomized Controlled Trial of Smoking Cessation Methods in Patients Newly-Diagnosed With Pulmonary Tuberculosis Publisher Pubmed



Aryanpur M1 ; Hosseini M2 ; Masjedi MR3 ; Mortaz E4, 5 ; Tabarsi P6 ; Soori H7 ; Emami H1 ; Heidari G1 ; Dizagie MK8 ; Baikpour M2
Authors
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Authors Affiliations
  1. 1. Shahid Beheshti University of Medical Sciences, Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran
  2. 2. Tehran University of Medical Sciences, Department of Epidemiology and Biostatistics, School of Public Health and Institute of Public Health Research, Tehran, Iran
  3. 3. Shahid Beheshti University of Medical Sciences, Ayatollah Taleghani Hospital, Evin, Tehran, Iran
  4. 4. Shahid Beheshti University of Medical Sciences, Department of Immunology, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran
  5. 5. Utrecht University, Division of Pharmacology and Pathophysiology Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht, Netherlands
  6. 6. Shahid Beheshti University of Medical Sciences, Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran
  7. 7. University of Medical Sciences, Safety Promotion and Injury Prevention research center of Shahid Beheshti, Tehran, Iran
  8. 8. Shahid Beheshti University of Medical Sciences, Mycobacteriology Research Center, Biostatistics unit, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran

Source: BMC Infectious Diseases Published:2016


Abstract

Background: Tuberculosis (TB) and tobacco use are two major alarming global health issues that tend to be co-prevalent in many developing countries and various surveys have provided evidence on their entangled associations. Accordingly, it is strongly suggested that smoking cessation be incorporated in TB control programs. Therefore, we aimed to evaluate the effectiveness of two smoking cessation methods among newly-diagnosed pulmonary TB patients. Methods: A total of 210 newly-diagnosed pulmonary TB patients from Tehran, Iran with smoking habits were included in this randomized clinical trial during 2012-2013. Patients were assigned to three groups of control (just TB medical treatment), brief advice (TB medical treatment plus individualized counseling sessions of quitting behavioral therapy) and combined intervention (TB medical treatment plus individualized counseling sessions of quitting behavioral therapy plus medical treatment with slow release bupropion). Patients' abstinence was followed at six time point during six months. Data were analyzed by SPSS v.22 using Generalized Estimating Equations (GEE) model. Results: Abstinance rate at the end of six months were 71.7 % for combined intervention group, 33.9 % for brief advice group and 9.8 % for the control group (p < 0.001). Combined intervention group and brief advice group respectively had 35 times (p < 0.001, OR = 35.26, 95 % CI = 13.77-90.32) and 7 times (p < 0.001, OR = 7.14, 95 % CI = 2.72-18.72) more odds of not being an active smoker at each time point, compared to the control group. Conclusion: Considering the prevalence and importance of TB and the substantial influence of these preventive measures on controlling tobacco use, application of such programs is recommended. Trial registration: The survey was registered in the Iranian registry of clinical trials website (irct.ir) in August 31, 2013 with IRCT ID: IRCT2013062613783N1. © 2016 The Author(s).
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1. The Effects of Smoking on Treatment Outcome in Patients Newly Diagnosed With Pulmonary Tuberculosis, International Journal of Tuberculosis and Lung Disease (2017)
2. Cigarette Smoking in Patients Newly Diagnosed With Pulmonary Tuberculosis in Iran, International Journal of Tuberculosis and Lung Disease (2016)
3. Intention to Quit Smoking and Associated Factors in Smokers Newly Diagnosed With Pulmonary Tuberculosis, Tanaffos (2016)
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