Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies

Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies Publisher

Motevasselian M¹ ; Saleh Gargari S¹ ; Younesi S² ; Pooransari P¹ ; Saadati P² ; Mirzamoradi M¹ ; Savad S² ; Taheri Amin MM² ; Modarresi MH³ ; Afrakhteh M¹ ; Ghafourifard S⁴

Show Affiliations

1. Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Prenatal Screening Department of Nilou Laboratory, Tehran, Iran
3. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Molecular Cytogenetics Published:2020

Abstract

Objectives: Recent years have witnessed a shift from invasive methods of prenatal screening to non-invasive strategies. Accordingly, non-invasive prenatal testing (NIPT) using cell-free fetal DNA in maternal plasma has gained a considerable deal of interest from both geneticists and obstetricians. Efficacy of this method in identification of common aneuploidies has been extensively assessed in singleton pregnancies. However, a limited number of studies have addressed the twin pregnancies. In this context, the present study is aimed at identification of the efficacy of NIPT in twin pregnancies. Methods: NIPT was performed on twin pregnancies to screen trisomies 13, 18 and 21. Pregnant women referring to Nilou Clinical Laboratory between March 2016 and December 2018 were included in this research. Results: In the current study, a total 356 twin pregnancies were screened in search for trisomies 13, 18 and 21. 6 cases exhibited positive NIPT results in which the presence of trisomies 13, 18 and 21 was confirmed by fetal karyotype in 1, 2 and 2 cases, respectively. One twin pregnancy showed normal karyotype. The combined false-positive rate for these trisomies was 0.28%. No false negative case was observed. The combined sensitivity and specificity of NIPT in twin pregnancies were 100 and 99.7%, respectively. Conclusion: The results of the current study verify the feasibility, sensitivity and specificity of NIPT in twin pregnancies. © 2020 The Author(s).

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Style	Citing Format
MLA	Motevasselian M, et al.. "Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies." Molecular Cytogenetics, vol. 13, no. 1, 2020, pp. -.
APA	Motevasselian M, Saleh Gargari S, Younesi S, Pooransari P, Saadati P, Mirzamoradi M, Savad S, Taheri Amin MM, Modarresi MH, Afrakhteh M, Ghafourifard S (2020). Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies. Molecular Cytogenetics, 13(1), -.
Chicago	Motevasselian M, Saleh Gargari S, Younesi S, Pooransari P, Saadati P, Mirzamoradi M, Savad S, et al.. "Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies." Molecular Cytogenetics 13, no. 1 (2020): -.
Harvard	Motevasselian M et al. (2020) 'Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies', Molecular Cytogenetics, 13(1), pp. -.
Vancouver	Motevasselian M, Saleh Gargari S, Younesi S, Pooransari P, Saadati P, Mirzamoradi M, et al.. Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies. Molecular Cytogenetics. 2020;13(1):-.
BibTex	@article{ author = {Motevasselian M and Saleh Gargari S and Younesi S and Pooransari P and Saadati P and Mirzamoradi M and Savad S and Taheri Amin MM and Modarresi MH and Afrakhteh M and Ghafourifard S}, title = {Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies}, journal = {Molecular Cytogenetics}, volume = {13}, number = {1}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Motevasselian M AU - Saleh Gargari S AU - Younesi S AU - Pooransari P AU - Saadati P AU - Mirzamoradi M AU - Savad S AU - Taheri Amin MM AU - Modarresi MH AU - Afrakhteh M AU - Ghafourifard S TI - Non-Invasive Prenatal Test to Screen Common Trisomies in Twin Pregnancies JO - Molecular Cytogenetics VL - 13 IS - 1 SP - EP - PY - 2020 ER -

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