Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide

Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide Publisher Pubmed

Irani M¹ ; Mir Mohamad Sadeghi G² ; Haririan I³

Show Affiliations

1. Department of Chemical Engineering, Amirkabir University of Technology, Tehran, Iran
2. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875, Tehran, 4413, Iran
3. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2017

Abstract

In the present study, the temozolomide (TMZ) loaded poly (ε-caprolactonediol) based polyurethane (PCL-Diol-b-PU) nanofibers were fabricated as local delivery systems against glioblastoma. The structure and morphology of nanofibers were characterized using FTIR and SEM analysis. The gold nanoparticles were coated on the nanofibers surface to enhance the efficacy of nanofibers for local chemotherapy of brain tumors. The effect of various ratios of DMF/THF solvents and solution concentration on the morphology and fiber diameter of PCL-Diol-b-PU nanofibers was investigated. The small burst release of TMZ with sustained TMZ release from both PCL-Diol-b-PU and gold-coated PCL-Diol-b-PU nanofibers were achieved over 30 days. The Korsmayer-Peppas kinetic and Fickian diffusion models were used to describe the mechanism of TMZ release from nanofibers. The in vitro cell viability results revealed that the higher antitumor activity of synthesized nanofibers against glioblastoma cells compared with pristine TMZ. It was concluded that the prepared nanofibrous implants showed a higher potential in the local chemotherapy of brain tumors. © 2017 Elsevier Masson SAS

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Mohammad Akrami (4)

Ismaeil Haririan (2)

Style	Citing Format
MLA	Irani M, Mir Mohamad Sadeghi G, Haririan I. "Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide." Biomedicine and Pharmacotherapy, vol. 88, no. , 2017, pp. 667-676.
APA	Irani M, Mir Mohamad Sadeghi G, Haririan I (2017). Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide. Biomedicine and Pharmacotherapy, 88(), 667-676.
Chicago	Irani M, Mir Mohamad Sadeghi G, Haririan I. "Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide." Biomedicine and Pharmacotherapy 88, no. (2017): 667-676.
Harvard	Irani M, Mir Mohamad Sadeghi G, Haririan I (2017) 'Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide', Biomedicine and Pharmacotherapy, 88(), pp. 667-676.
Vancouver	Irani M, Mir Mohamad Sadeghi G, Haririan I. Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide. Biomedicine and Pharmacotherapy. 2017;88():667-676.
BibTex	@article{ author = {Irani M and Mir Mohamad Sadeghi G and Haririan I}, title = {Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide}, journal = {Biomedicine and Pharmacotherapy}, volume = {88}, number = {}, pages = {667-676}, year = {2017} }
RIS	TY - JOUR AU - Irani M AU - Mir Mohamad Sadeghi G AU - Haririan I TI - Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide JO - Biomedicine and Pharmacotherapy VL - 88 IS - SP - 667 EP - 676 PY - 2017 ER -

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