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Levofloxacin Loaded Poly (Ethylene Oxide)-Chitosan/Quercetin Loaded Poly (D,L-Lactide-Co-Glycolide) Core-Shell Electrospun Nanofibers for Burn Wound Healing Publisher



Monavari M1 ; Sohrabi R1 ; Motasadizadeh H2 ; Monavari M1 ; Fatahi Y4, 5 ; Ejarestaghi NM6 ; Fuenteschandia M7 ; Lealegana A8 ; Akrami M1, 9 ; Homaeigohar S10
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Section eScience (S.3), Federal Institute for Materials Research and Testing, Berlin, Germany
  4. 4. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, OH, United States
  8. 8. Institute for Molecular Systems Engineering and Advanced Materials, Heidelberg University, Heidelberg, Germany
  9. 9. Institute of Biomaterials, University of Tehran & Tehran University of Medical Sciences (IBUTUMS), Tehran, Iran
  10. 10. School of Science and Engineering, University of Dundee, Dundee, United Kingdom

Source: Frontiers in Bioengineering and Biotechnology Published:2024


Abstract

This study developed a new burn wound dressing based on core-shell nanofibers that co-deliver antibiotic and antioxidant drugs. For this purpose, poly(ethylene oxide) (PEO)-chitosan (CS)/poly(D,L-lactide-co-glycolide) (PLGA) core-shell nanofibers were fabricated through co-axial electrospinning technique. Antibiotic levofloxacin (LEV) and antioxidant quercetin (QS) were incorporated into the core and shell parts of PEO-CS/PLGA nanofibers, respectively. The drugs could bond to the polymer chains through hydrogen bonding, leading to their steady release for 168 h. An in vitro drug release study showed a burst effect followed by sustained release of LEV and QS from the nanofibers due to the Fickian diffusion. The NIH 3T3 fibroblast cell viability of the drug loaded core-shell nanofibers was comparable to that in the control (tissue culture polystyrene) implying biocompatibility of the nanofibers and their cell supportive role. However, there was no significant difference in cell viability between the drug loaded and drug free core-shell nanofibers. According to in vivo experiments, PEO-CS-LEV/PLGA-QS core-shell nanofibers could accelerate the healing process of a burn wound compared to a sterile gauze. Thanks to the synergistic therapeutic effect of LEV and QS, a significantly higher wound closure rate was recorded for the drug loaded core-shell nanofibrous dressing than the drug free nanofibers and control. Conclusively, PEO-CS-LEV/PLGA-QS core-shell nanofibers were shown to be a promising wound healing material that could drive the healing cascade through local co-delivery of LEV and QS to burn wounds. Copyright © 2024 Monavari, Sohrabi, Motasadizadeh, Monavari, Fatahi, Ejarestaghi, Fuentes-Chandia, Leal-Egana, Akrami and Homaeigohar.
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