Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries

Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries Publisher Pubmed

Liu Z¹ ; Liu R^{2, 3} ; Gao H¹ ; Jung S⁴ ; Gao X^{1, 69} ; Sun R¹ ; Liu X⁵ ; Kim Y⁴ ; Lee HS⁴ ; Kawai Y⁶ ; Nagasaki M^{7, 8} ; Umeno J⁹ ; Tokunaga K⁶ ; Kinouchi Y¹⁰ Show All Authors

Liu Z¹
Liu R^{2, 3}
Gao H¹
Jung S⁴
Gao X^{1, 69}
Sun R¹
Liu X⁵
Kim Y⁴
Lee HS⁴
Kawai Y⁶
Nagasaki M^{7, 8}
Umeno J⁹
Tokunaga K⁶
Kinouchi Y¹⁰
Masamune A¹¹
Shi W¹²
Shen C¹²
Guo Z³
Yuan K^{2, 3}
Abreu M²⁵
Achkar JP²⁶
Andersen V²⁷
Bernstein C²⁸
Brant SR²⁹
Bujanda L³⁰
Ng SC³¹
Denson LA³²
Duerr RH³³
Ferguson LR³⁴
Franchimont D³⁵
Franke A³⁶
Gearry R³⁷
Hakonarson H³⁸
Halfvarson J³⁹
Heller C⁴⁰
Julia A⁴¹
Kelsen J³⁸
Khalili H⁴²
Kugathasan S⁴³
Kupcinskas J⁴⁴
Latiano A⁴⁵
Louis E⁴⁶
Malekzadeh R⁴⁷
Mccauley JL⁴⁸
Moran C⁴⁹
Okou D⁴³
Orchard T⁵⁰
Palotie A^{2, 3, 21}
Parkes M⁵¹
Pekow J⁵²
Potocnik U⁵³
Radfordsmith G⁵⁴
Rioux JD⁵⁵
Rogler G⁵⁶
Sands B⁵⁷
Silverberg M⁵⁸
Sokol H⁵⁹
Vermeire S⁶⁰
Weersma RK⁶¹
Xavier RJ⁶²
Hu N⁶³
Cao Q⁶⁴
Wang Y⁶⁵
Miao Y⁶⁶
Zhang H⁶⁷
Lv X⁶⁸
Zhang H⁶⁷
Su J⁷⁰
Feng B⁷¹
Zhao Y⁷²
Zhu L⁷³
Chen Y⁷⁴
Zhu L⁷³
Chen C⁷⁶
Wang Y⁶⁵
Wang Y⁶⁵
Pang Z⁷⁹
Chen Y⁷⁴
Zhang X⁸¹
Li H⁸²
Yu Q⁸³
Ye M⁸⁴
Zhang S⁸⁵
Tang W⁸⁶
Wang M⁸⁷
Cao X⁸⁸
Zhu R⁸⁹
Zhou G⁹⁰
Bian Z⁹¹
Guo X⁹²
Wu X⁹³
Liu J⁹⁴
Xu W⁹⁵
Li Y⁹⁶
Guo Q⁹⁷
Guo Z³
Zhu S¹³
Li D¹⁴
Liu J⁹⁴
Ge T^{17, 18, 19}
Cho J²⁰
Daly MJ^{2, 21, 22}
Mcgovern DPB¹⁴
Ye BD²³
Song K⁴
Kakuta Y¹¹
Li M⁵
Huang H^{2, 3, 24}

Source: Nature Genetics Published:2023

Abstract

Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with the following two subtypes: Crohn’s disease (CD) and ulcerative colitis (UC). To date, most IBD genetic associations were derived from individuals of European (EUR) ancestries. Here we report the largest IBD study of individuals of East Asian (EAS) ancestries, including 14,393 cases and 15,456 controls. We found 80 IBD loci in EAS alone and 320 when meta-analyzed with ~370,000 EUR individuals (~30,000 cases), among which 81 are new. EAS-enriched coding variants implicate many new IBD genes, including ADAP1 and GIT2. Although IBD genetic effects are generally consistent across ancestries, genetics underlying CD appears more ancestry dependent than UC, driven by allele frequency (NOD2) and effect (TNFSF15). We extended the IBD polygenic risk score (PRS) by incorporating both ancestries, greatly improving its accuracy and highlighting the importance of diversity for the equitable deployment of PRS. © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.

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Style	Citing Format
MLA	Liu Z, et al.. "Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries." Nature Genetics, vol. 55, no. 5, 2023, pp. 796-806.
APA	Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, Liu X, Kim Y, Lee HS, Kawai Y, Nagasaki M, Umeno J, Tokunaga K, Kinouchi Y, Masamune A, Shi W, Shen C, Guo Z, Yuan K, ... Huang H (2023). Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries. Nature Genetics, 55(5), 796-806.
Chicago	Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, Liu X, et al.. "Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries." Nature Genetics 55, no. 5 (2023): 796-806.
Harvard	Liu Z et al. (2023) 'Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries', Nature Genetics, 55(5), pp. 796-806.
Vancouver	Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, et al.. Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries. Nature Genetics. 2023;55(5):796-806.
BibTex	@article{ author = {Liu Z and Liu R and Gao H and Jung S and Gao X and Sun R and Liu X and Kim Y and Lee HS and Kawai Y and Nagasaki M and Umeno J and Tokunaga K and Kinouchi Y and Masamune A and Shi W and Shen C and Guo Z and Yuan K and Abreu M and Achkar JP and Andersen V and Bernstein C and Brant SR and Bujanda L and Ng SC and Denson LA and Duerr RH and Ferguson LR and Franchimont D and Franke A and Gearry R and Hakonarson H and Halfvarson J and Heller C and Julia A and Kelsen J and Khalili H and Kugathasan S and Kupcinskas J and Latiano A and Louis E and Malekzadeh R and Mccauley JL and Moran C and Okou D and Orchard T and Palotie A and Parkes M and Pekow J and Potocnik U and Radfordsmith G and Rioux JD and Rogler G and Sands B and Silverberg M and Sokol H and Vermeire S and Weersma RK and Xavier RJ and Hu N and Cao Q and Wang Y and Miao Y and Zhang H and Lv X and Zhang H and Su J and Feng B and Zhao Y and Zhu L and Chen Y and Zhu L and Chen C and Wang Y and Wang Y and Pang Z and Chen Y and Zhang X and Li H and Yu Q and Ye M and Zhang S and Tang W and Wang M and Cao X and Zhu R and Zhou G and Bian Z and Guo X and Wu X and Liu J and Xu W and Li Y and Guo Q and Guo Z and Zhu S and Li D and Liu J and Ge T and Cho J and Daly MJ and Mcgovern DPB and Ye BD and Song K and Kakuta Y and Li M and Huang H}, title = {Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries}, journal = {Nature Genetics}, volume = {55}, number = {5}, pages = {796-806}, year = {2023} }
RIS	TY - JOUR AU - Liu Z AU - Liu R AU - Gao H AU - Jung S AU - Gao X AU - Sun R AU - Liu X AU - Kim Y AU - Lee HS AU - Kawai Y AU - Nagasaki M AU - Umeno J AU - Tokunaga K AU - Kinouchi Y AU - Masamune A AU - Shi W AU - Shen C AU - Guo Z AU - Yuan K AU - Abreu M AU - Achkar JP AU - Andersen V AU - Bernstein C AU - Brant SR AU - Bujanda L AU - Ng SC AU - Denson LA AU - Duerr RH AU - Ferguson LR AU - Franchimont D AU - Franke A AU - Gearry R AU - Hakonarson H AU - Halfvarson J AU - Heller C AU - Julia A AU - Kelsen J AU - Khalili H AU - Kugathasan S AU - Kupcinskas J AU - Latiano A AU - Louis E AU - Malekzadeh R AU - Mccauley JL AU - Moran C AU - Okou D AU - Orchard T AU - Palotie A AU - Parkes M AU - Pekow J AU - Potocnik U AU - Radfordsmith G AU - Rioux JD AU - Rogler G AU - Sands B AU - Silverberg M AU - Sokol H AU - Vermeire S AU - Weersma RK AU - Xavier RJ AU - Hu N AU - Cao Q AU - Wang Y AU - Miao Y AU - Zhang H AU - Lv X AU - Zhang H AU - Su J AU - Feng B AU - Zhao Y AU - Zhu L AU - Chen Y AU - Zhu L AU - Chen C AU - Wang Y AU - Wang Y AU - Pang Z AU - Chen Y AU - Zhang X AU - Li H AU - Yu Q AU - Ye M AU - Zhang S AU - Tang W AU - Wang M AU - Cao X AU - Zhu R AU - Zhou G AU - Bian Z AU - Guo X AU - Wu X AU - Liu J AU - Xu W AU - Li Y AU - Guo Q AU - Guo Z AU - Zhu S AU - Li D AU - Liu J AU - Ge T AU - Cho J AU - Daly MJ AU - Mcgovern DPB AU - Ye BD AU - Song K AU - Kakuta Y AU - Li M AU - Huang H TI - Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries JO - Nature Genetics VL - 55 IS - 5 SP - 796 EP - 806 PY - 2023 ER -

Style

Citing Format

MLA

Liu Z, et al.. "Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries." Nature Genetics, vol. 55, no. 5, 2023, pp. 796-806.

APA

Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, Liu X, Kim Y, Lee HS, Kawai Y, Nagasaki M, Umeno J, Tokunaga K, Kinouchi Y, Masamune A, Shi W, Shen C, Guo Z, Yuan K, ... Huang H (2023). Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries. Nature Genetics, 55(5), 796-806.

Chicago

Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, Liu X, et al.. "Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries." Nature Genetics 55, no. 5 (2023): 796-806.

Harvard

Liu Z et al. (2023) 'Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries', Nature Genetics, 55(5), pp. 796-806.

Vancouver

Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, et al.. Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries. Nature Genetics. 2023;55(5):796-806.

BibTex

@article{ author = {Liu Z and Liu R and Gao H and Jung S and Gao X and Sun R and Liu X and Kim Y and Lee HS and Kawai Y and Nagasaki M and Umeno J and Tokunaga K and Kinouchi Y and Masamune A and Shi W and Shen C and Guo Z and Yuan K and Abreu M and Achkar JP and Andersen V and Bernstein C and Brant SR and Bujanda L and Ng SC and Denson LA and Duerr RH and Ferguson LR and Franchimont D and Franke A and Gearry R and Hakonarson H and Halfvarson J and Heller C and Julia A and Kelsen J and Khalili H and Kugathasan S and Kupcinskas J and Latiano A and Louis E and Malekzadeh R and Mccauley JL and Moran C and Okou D and Orchard T and Palotie A and Parkes M and Pekow J and Potocnik U and Radfordsmith G and Rioux JD and Rogler G and Sands B and Silverberg M and Sokol H and Vermeire S and Weersma RK and Xavier RJ and Hu N and Cao Q and Wang Y and Miao Y and Zhang H and Lv X and Zhang H and Su J and Feng B and Zhao Y and Zhu L and Chen Y and Zhu L and Chen C and Wang Y and Wang Y and Pang Z and Chen Y and Zhang X and Li H and Yu Q and Ye M and Zhang S and Tang W and Wang M and Cao X and Zhu R and Zhou G and Bian Z and Guo X and Wu X and Liu J and Xu W and Li Y and Guo Q and Guo Z and Zhu S and Li D and Liu J and Ge T and Cho J and Daly MJ and Mcgovern DPB and Ye BD and Song K and Kakuta Y and Li M and Huang H}, title = {Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries}, journal = {Nature Genetics}, volume = {55}, number = {5}, pages = {796-806}, year = {2023} }

RIS

TY - JOUR
AU - Liu Z
AU - Liu R
AU - Gao H
AU - Jung S
AU - Gao X
AU - Sun R
AU - Liu X
AU - Kim Y
AU - Lee HS
AU - Kawai Y
AU - Nagasaki M
AU - Umeno J
AU - Tokunaga K
AU - Kinouchi Y
AU - Masamune A
AU - Shi W
AU - Shen C
AU - Guo Z
AU - Yuan K
AU - Abreu M
AU - Achkar JP
AU - Andersen V
AU - Bernstein C
AU - Brant SR
AU - Bujanda L
AU - Ng SC
AU - Denson LA
AU - Duerr RH
AU - Ferguson LR
AU - Franchimont D
AU - Franke A
AU - Gearry R
AU - Hakonarson H
AU - Halfvarson J
AU - Heller C
AU - Julia A
AU - Kelsen J
AU - Khalili H
AU - Kugathasan S
AU - Kupcinskas J
AU - Latiano A
AU - Louis E
AU - Malekzadeh R
AU - Mccauley JL
AU - Moran C
AU - Okou D
AU - Orchard T
AU - Palotie A
AU - Parkes M
AU - Pekow J
AU - Potocnik U
AU - Radfordsmith G
AU - Rioux JD
AU - Rogler G
AU - Sands B
AU - Silverberg M
AU - Sokol H
AU - Vermeire S
AU - Weersma RK
AU - Xavier RJ
AU - Hu N
AU - Cao Q
AU - Wang Y
AU - Miao Y
AU - Zhang H
AU - Lv X
AU - Zhang H
AU - Su J
AU - Feng B
AU - Zhao Y
AU - Zhu L
AU - Chen Y
AU - Zhu L
AU - Chen C
AU - Wang Y
AU - Wang Y
AU - Pang Z
AU - Chen Y
AU - Zhang X
AU - Li H
AU - Yu Q
AU - Ye M
AU - Zhang S
AU - Tang W
AU - Wang M
AU - Cao X
AU - Zhu R
AU - Zhou G
AU - Bian Z
AU - Guo X
AU - Wu X
AU - Liu J
AU - Xu W
AU - Li Y
AU - Guo Q
AU - Guo Z
AU - Zhu S
AU - Li D
AU - Liu J
AU - Ge T
AU - Cho J
AU - Daly MJ
AU - Mcgovern DPB
AU - Ye BD
AU - Song K
AU - Kakuta Y
AU - Li M
AU - Huang H
TI - Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries
JO - Nature Genetics
VL - 55
IS - 5
SP - 796
EP - 806
PY - 2023
ER -

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