Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode

Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode Publisher Pubmed

Moghimi S^{1, 2} ; Safizadeh M² ; Fard MA² ; Motamedgorji N² ; Khatibi N² ; Chen R³ ; Weinreb RN¹

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1. Hamilton Glaucoma Center, Shiley Eye Institute, The Viterbi Family Department of Ophthalmology, University of California San Diego, San Diego, CA, United States
2. Tehran University of Medical Sciences, Tehran, Iran
3. Case Western Reserve University School of Medicine, Cleveland, OH, United States

Source: Investigative Ophthalmology and Visual Science Published:2019

Abstract

PURPOSE. To evaluate the changes in circumpapillary vessel density (cpVD) and retinal nerve fiber layer (RNFL) thickness after an acute primary angle closure (APAC) episode. METHODS. Twenty-eight patients (28 pair of eyes) with unilateral APAC and 39 normal subjects (64 eyes) were included in this prospective, observational study. cpVD as measured by optical coherence tomography angiography and RNFL thickness as measured by spectral-domain optical coherence tomography were compared at 6 weeks after an APAC episode between affected, unaffected, and normal eyes. cpVD and RNFL thickness at 1 week and 6 weeks after APAC were also compared in APAC eyes in qualified images. RESULTS. At 6 weeks, cpVD was significantly lower in APAC eyes (57.3% ± 6.8%), compared to fellow eyes (63.1% ± 3.5%) and control eyes (63.6% ± 3.4%) (P < 0.001). There was diffuse microvascular dropout with greater vessel density loss in the superonasal sector. APAC eyes had thinner RNFL globally and in each sector (except temporal and nasal sectors) than in fellow and normal eyes at 6 weeks. cpVD in the affected eyes was significantly greater at 1 week (56.3% ± 5.3%) than values at 6 weeks (53.5% ± 7%) (P = 0.003) but less than cpVD in the fellow eyes (62.4% ± 5.0%) (P < 0.001). RNFL thickness for the APAC eyes at 1 week (120.6 6 18.0 µm) was greater than the analogous values for affected eyes (90.1 ± 13.2 µm; P = 0.037) and fellow eyes at 6 weeks (102.5 ± 5.7 µm; P = 0.001). CONCLUSIONS. Vessel density decreased over 6 weeks after an APAC episode compared with the contralateral unaffected eyes. In contrast, © 2019 The Authors. © 2019, Association for Research in Vision and Ophthalmology Inc.. All rights reserved.

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Masoud Aghsaei Fard (8)

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Style	Citing Format
MLA	Moghimi S, et al.. "Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode." Investigative Ophthalmology and Visual Science, vol. 60, no. 2, 2019, pp. 552-558.
APA	Moghimi S, Safizadeh M, Fard MA, Motamedgorji N, Khatibi N, Chen R, Weinreb RN (2019). Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode. Investigative Ophthalmology and Visual Science, 60(2), 552-558.
Chicago	Moghimi S, Safizadeh M, Fard MA, Motamedgorji N, Khatibi N, Chen R, Weinreb RN. "Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode." Investigative Ophthalmology and Visual Science 60, no. 2 (2019): 552-558.
Harvard	Moghimi S et al. (2019) 'Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode', Investigative Ophthalmology and Visual Science, 60(2), pp. 552-558.
Vancouver	Moghimi S, Safizadeh M, Fard MA, Motamedgorji N, Khatibi N, Chen R, et al.. Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode. Investigative Ophthalmology and Visual Science. 2019;60(2):552-558.
BibTex	@article{ author = {Moghimi S and Safizadeh M and Fard MA and Motamedgorji N and Khatibi N and Chen R and Weinreb RN}, title = {Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode}, journal = {Investigative Ophthalmology and Visual Science}, volume = {60}, number = {2}, pages = {552-558}, year = {2019} }
RIS	TY - JOUR AU - Moghimi S AU - Safizadeh M AU - Fard MA AU - Motamedgorji N AU - Khatibi N AU - Chen R AU - Weinreb RN TI - Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode JO - Investigative Ophthalmology and Visual Science VL - 60 IS - 2 SP - 552 EP - 558 PY - 2019 ER -

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