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Does Vitamin D Supplementation Impact Serotonin Levels? a Systematic Review and Meta-Analysis Publisher



Alimohammadikamalabadi M1 ; Ziaei S2 ; Hasani M3 ; Mohammadi S4 ; Mehrbod M5 ; Morvaridi M6 ; Persad E7 ; Belancic A8 ; Malekahmadi M9 ; Estevao MDDMADO10 ; Daneshzad E11 ; Heshmati J12
Authors
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Authors Affiliations
  1. 1. Department of Cellular-Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. ICU Department, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Nutritional Sciences, School of Health, Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  5. 5. Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department for Evidence-based Medicine and Evaluation, Danube University Krems, Krems, Austria
  8. 8. Department of Basic and Clinical Pharmacology with Toxicology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
  9. 9. Imam Khomeini Hospital Complex, Tehran University of Medicinal Sciences Tehran Iran, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Universidade do Algarve, Escola Superior de Saude, Campus de Gambelas, Faro, Portugal
  11. 11. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  12. 12. University of Ottawa Heart Institute, Ottawa, ON, Canada

Source: Health Science Reports Published:2024


Abstract

Background and Aims: Vitamin D deficiency impacts a significant proportion of the world's population, and this deficiency has been linked to various conditions characterized by imbalanced serotonin regulation. The objective of this systematic review and meta-analysis was to evaluate the effect of vitamin D supplementation on serum serotonin levels. Methods: We conducted a comprehensive search of PubMed, Scopus, Cochrane Central for Randomized Clinical Trials, and Web of Science up to September 2022, without any language restrictions. The effect sizes were calculated using the standard mean difference (SMD) and 95% confidence interval (CI). Results: Six randomized clinical trials involving 356 participants were included in the analysis. Our findings indicated no significant changes in serotonin levels between the intervention and control groups (SMD: 0.24 ng/mL, 95% CI: −0.28, 0.75, p > 0.10). Subgroup analysis also did not reveal any significant changes in serotonin levels among children, participants with autism spectrum disorders, interventions lasting 10 weeks or longer, or those receiving vitamin D doses below 4000 IU/day. Conclusion: Although the results obtained in this systematic review are inconclusive, they support the need for further well-designed randomized trials to assess the potential role of vitamin D supplementation in regulating serotonin levels and potentially ameliorating depression and related disorders. © 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
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