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Interactions Between Vitamin D Binding Protein Variants and Major Dietary Patterns on Mental Health Status in Apparently Healthy Adults Publisher



Nasir Y1 ; Niknam A2 ; Rahimi MH1 ; Molahosseini M3, 4 ; Mirzaei K1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Clinical Psychology, North Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran
  4. 4. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: European Journal of Integrative Medicine Published:2024


Abstract

Introduction: Recent studies have shown that the risks of mental disorders resulting from vitamin D deficiency, such as depression, anxiety and stress, can be affected by various high-risk alleles. Among the genes interacting with environmental factors are those associated with vitamin D binding protein (DBP) that affects the status of 25- OH vitamin D. Therefore, the present study aimed to determine the interaction between dietary patterns and DBP gene variants on mental health status in adults. Methods: This cross-sectional study was conducted on a random sample of adult participants (n = 265 and 18–55 years old) in Tehran. Major dietary patterns were determined using principal component analysis (PCA) method on 24 food groups, using a valid and reliable 147-item food frequency questionnaire (FFQ). DBP genotypes were determined by polymerase chain reactions - restriction fragment length polymorphism (PCR-RFLP). Data about the mental health status were collected using the Depression, Anxiety, Stress Score (DASS-21). Results: Results demonstrated strong interactions between higher adherence to healthy dietary patterns in individuals with the major allele (low-risk allele) carriers of rs7041 (GG genotype), in relation to reduced stress score (OR= -2.54, 95 % CI = -4.60 to -0.48, P interaction = 0.02). Also, individuals with higher adherence to healthy dietary patterns with GG genotype of rs7041 indicated reduced stress score, but it was not significant (OR = -1.84, 95 % CI = 0.18 to -3.86, P interaction = 0.07). Conclusion: The present evidence indicates that interactions between healthy dietary patterns with DBP variants (rs7041 - GG genotype) may effectively reduce the odds of mental disorders, especially in stress, through consuming healthy food groups and inherited low-risk alleles. © 2024 Elsevier GmbH
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