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The Association of Vitamin D Status With Lipid Profile and Inflammation Biomarkers in Healthy Adolescents Publisher Pubmed



Yarparvar A1, 2 ; Elmadfa I1 ; Djazayery A3 ; Abdollahi Z4 ; Salehi F5
Authors
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Authors Affiliations
  1. 1. School of Nutrition, University of Vienna, Vienna, 1090, Austria
  2. 2. Health and Nutrition Specialist for UNICEF Regional Office for Europe and Central Asia, Almaty, 050000, Kazakhstan
  3. 3. School of Nutrition and Dietetics, Tehran University of Medical Science, Tehran, 14155/6117, Iran
  4. 4. Nutrition Department of the Ministry of health and Medical Education, Tehran, 1467664961, Iran
  5. 5. Deputy Director of Family Health Department of the Ministry of health and Medical Education, Tehran, 1467664961, Iran

Source: Nutrients Published:2020


Abstract

Background: The association between vitamin D status and inflammatory biomarkers and lipid profile is not well known, especially in adolescents. Therefore, the aim of the current study is to investigate the association of vitamin D status with serum lipids and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, in male adolescents. Methods and materials: A sample of seventy-one high school male students, aged 17 years old, from a high school in Tehran were enrolled in the study. They were divided into four groups including group with serum vitamin D below 25 (ng/mL) (SVD < 25; n = 36), 25 and above (ng/mL) (SVD ≥ 25; n = 35), negative-hsCRP (n = 48), and positive-hsCRP (n = 23). Weight, height, body mass index, dietary intake, serum lipids, and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, were measured. Results: In the (SVD < 25) group, the serum level of TNFR-2 was significantly higher compared to that in the (SVD ≥ 25) group. There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. We found significant lower levels of IL-10 in positive-hsCRP group compared to the negative-hsCRP group. In addition, there was a significant negative correlation between the serum vitamin D level and hsCRP in both hsCRP groups. The HDL level was lower in the (SVD < 25) group compared to that in the (SVD ≥ 25) group. Finally, there was a negative correlation between the serum HDL and hsCRP levels in the positive-hsCRP subjects. Conclusion: Based on the findings it can be concluded that serum vitamin D affects HDL and inflammation status. Although serum levels of HDL and inflammation status are both predictors of metabolic syndrome and cardiovascular disease, further studies are needed to prove it, especially in adolescents. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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