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Micro-Rnas As Critical Regulators of Matrix Metalloproteinases in Cancer Publisher Pubmed



Noruzi S1 ; Azizian M2 ; Mohammadi R1 ; Hosseini SA1 ; Rashidi B3 ; Mohamadi Y4, 5 ; Nesaei A6 ; Seiri P7 ; Sahebkar A8, 11 ; Salarinia R1 ; Aghdam AM9 ; Mirzaei H10
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology and Molecular Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnourd, Iran
  2. 2. Department of Clinical Biochemistry, Ftabaculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
  3. 3. Department of Anatomical Sciences, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Anatomy, Faculty of medicine, Qom University of Medical Sciences, Qom, Iran
  6. 6. Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
  7. 7. Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Cellular Biochemistry Published:2018


Abstract

Metastasis is known to be one of the important factors associated with cancer-related deaths worldwide. Several cellular and molecular targets are involved in the metastasis process. Among these targets, matrix metalloproteinases (MMPs) play central roles in promoting cancer metastasis. MMPs could contribute toward tumor growth, angiogenesis, migration, and invasion via degradation of the extracellular matrix and activation of pre-pro–growth factors. Therefore, identification of various cellular and molecular pathways that affect MMPs could contribute toward a better understanding of the metastatic pathways involved in various tumors. Micro-RNAs are important targets that could affect MMPs. Multiple lines of evidence have indicated that deregulation of various micro-RNAs, including miR-9, Let-7, miR-10b, and miR-15b, affects metastasis of tumor cells via targeting MMPs. © 2018 Wiley Periodicals, Inc.
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