Micro-Rnas As Critical Regulators of Matrix Metalloproteinases in Cancer Publisher Pubmed



Noruzi S¹ ; Azizian M² ; Mohammadi R¹ ; Hosseini SA¹ ; Rashidi B³ ; Mohamadi Y^{4, 5} ; Nesaei A⁶ ; Seiri P⁷ ; Sahebkar A^{8, 11} ; Salarinia R¹ ; Aghdam AM⁹ ; Mirzaei H¹⁰
Source: Journal of Cellular Biochemistry Published:2018

Abstract

Metastasis is known to be one of the important factors associated with cancer-related deaths worldwide. Several cellular and molecular targets are involved in the metastasis process. Among these targets, matrix metalloproteinases (MMPs) play central roles in promoting cancer metastasis. MMPs could contribute toward tumor growth, angiogenesis, migration, and invasion via degradation of the extracellular matrix and activation of pre-pro–growth factors. Therefore, identification of various cellular and molecular pathways that affect MMPs could contribute toward a better understanding of the metastatic pathways involved in various tumors. Micro-RNAs are important targets that could affect MMPs. Multiple lines of evidence have indicated that deregulation of various micro-RNAs, including miR-9, Let-7, miR-10b, and miR-15b, affects metastasis of tumor cells via targeting MMPs. © 2018 Wiley Periodicals, Inc.