Therapeutic Application of Multipotent Stem Cells Publisher Pubmed



Mirzaei H¹ ; Sahebkar A² ; Sichani LS³ ; Moridikia A⁴ ; Nazari S⁵ ; Nahand JS⁶ ; Salehi H⁷ ; Stenvang J⁸ ; Masoudifar A⁹ ; Mirzaei HR¹⁰ ; Jaafari MR¹¹
Source: Journal of Cellular Physiology Published:2018

Abstract

Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self-renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti-inflammatory and antiapoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications. © 2017 Wiley Periodicals, Inc.