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Improving Curcumin Constraints With Ph-Responsive Chitosan Based Graphene Oxide/Montmorillonite Nanohybrid Modified Agarose in Breast Cancer Therapy Publisher



Rajaei M1 ; Pourmadadi M6 ; Rashedi H1 ; Yazdian F2 ; Navaeinigjeh M3 ; Rahdar A4 ; Ferreira LFR5
Authors
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Authors Affiliations
  1. 1. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Department of Life Science Engineering, Faculty of New Science and Technologies, University of Tehran, Tehran, Iran
  3. 3. Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Physics, Faculty of Sciences, University of Zabol, Zabol, 538-98615, Iran
  5. 5. Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Brasilia, 71.966-700, Brazil
  6. 6. Protein Research Center, Shahid Beheshti University, GC, Tehran, 1983963113, Iran

Source: BioNanoScience Published:2024


Abstract

Nanoparticles have promisingly served as therapeutic agents in drug delivery systems to supress side effects while improving the effectiveness of treatment to deadly cancers. The present study aims to fabricate chitosan/agarose/graphene oxide/montmorillonite nanocomposites to serve as drug carriers for the prolonged release of curcumin to suppress MCF7 breast cancer cells. Offering a range of advantages, including biocompatibility and pH-sensitivity, the nanocomposites were synthesized via a water-in-oil-in-water (W/O/W) emulsification technique. Characterization studies were conducted with FTIR and XRD analyses. Dynamic light scattering (DLS) analysis was conducted to measure the mean size of the produced nanoscale emulsions, with zeta potential assessments further performed to characterize the nanocomposites in terms of surface charge. FE-SEM imagery indicated the uniform and flat surface of the synthesized nanocomposites. MTT assay results showed that the nanocomposites were most toxic to MCF7 breast cancer cells. The occurrence of apoptosis to MCF7 breast cancer cells was evident from the flow cytometry findings. Implementing a dialysis procedure, the curcumin was found to be released at a higher rate in acidic media. Altogether, our findings proved that the designed CS/AG/GO/MMT@CUR nanocomposites could be a drug carrier for treating breast cancer cells. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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