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Preparation of Ph-Sensitive Chitosan/Polyvinylpyrrolidone/Α-Fe2o3 Nanocomposite for Drug Delivery Application: Emphasis on Ameliorating Restrictions Publisher Pubmed



Gerami SE1 ; Pourmadadi M1 ; Fatoorehchi H1 ; Yazdian F2 ; Rashedi H3 ; Nigjeh MN4
Authors
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Authors Affiliations
  1. 1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Department of Life Science Engineering, Faculty of New Science and Technologies, University of Tehran, Tehran, Iran
  3. 3. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  4. 4. Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Science, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2021


Abstract

Chitosan (CS)/polyvinylpyrrolidone (PVP)/hematite (α-Fe2O3) nanocomposites loaded with Doxorubicin (drug model) were synthesized via an oil-in-water emulsification method to develop a biocompatible and pH-sensitive drug nanocarrier for the first time. A hydrogel, including CS, PVP, and α-Fe2O3, was fabricated successfully with glutaraldehyde (GA) as the cross-linker. Incorporating α-Fe2O3 into CS/PVP hydrogel improved the pH-sensitivity and developed beneficial hydrogel. FTIR and XRD analysis illustrated physical interactions between polymer-polymer, polymer-drug, and crystalline behavior of prepared nanocomposite. These analyses also confirmed chemical bonding in nanocomposite's structure. The FE-SEM analysis showed successful impregnation of α-Fe2O3 into CS/PVP matrix and spherical structure. To clarify the size distribution and surface charge of the drug-loaded nanocomposite (CS/PVP/α-Fe2O3/Dox), DLS and zeta analyses were conducted. They showed the mean size of nanocomposites at about 247 nm. Drug-loaded CS/PVP/α-Fe2O3 nanocomposite and CS/PVP/Dox were studied for their release behavior and kinetics. Furthermore, the effect of α-Fe2O3 on release from CS/PVP/α-Fe2O3/Dox nanocomposite was investigated. That showed an increase in encapsulation of Doxorubicin and beneficial release behavior such as slow-release and retention effect. The release from this drug-loaded nanocomposite revealed excellent pH-sensitive and controlled release of the drug. Besides, the in vitro cytotoxicity and cell apoptosis were studied to recognize biological properties. These analyses revealed that drug-loaded nanocomposite caused high inhibition to MCF-7 cells in presence of α-Fe2O3 and proved the hematite's anti-cancer effect. By and large, this study confirmed CS/PVP/α-Fe2O3 nanocomposites as a potential candidate for the controlled pH-sensitive release of the drug. © 2021
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