Targeting Autophagy in Cardiac Ischemia/Reperfusion Injury: A Novel Therapeutic Strategy Publisher Pubmed



Aghaei M¹ ; Motallebnezhad M^{2, 3, 4} ; Ghorghanlu S⁵ ; Jabbari A⁵ ; Enayati A^{5, 6} ; Rajaei M⁵ ; Pourabouk M⁵ ; Moradi A⁷ ; Alizadeh AM⁸ ; Khori V⁵
Source: Journal of Cellular Physiology Published:2019

Abstract

Acute myocardial infarction (AMI) is one of the leading causes of morbidity worldwide. Myocardial reperfusion is known as an effective therapeutic choice against AMI. However, reperfusion of blood flow induces ischemia/reperfusion (I/R) injury through different complex processes including ion accumulation, disruption of mitochondrial membrane potential, the formation of reactive oxygen species, and so forth. One of the processes that gets activated in response to I/R injury is autophagy. Indeed, autophagy acts as a “double-edged sword” in the pathology of myocardial I/R injury and there is a controversy about autophagy being beneficial or detrimental. On the basis of the autophagy effect and regulation on myocardial I/R injury, many studies targeted it as a therapeutic strategy. In this review, we discuss the role of autophagy in I/R injury and its targeting as a therapeutic strategy. © 2019 Wiley Periodicals, Inc.