Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Targeting Autophagy in Cardiac Ischemia/Reperfusion Injury: A Novel Therapeutic Strategy Publisher Pubmed



Aghaei M1 ; Motallebnezhad M2, 3, 4 ; Ghorghanlu S5 ; Jabbari A5 ; Enayati A5, 6 ; Rajaei M5 ; Pourabouk M5 ; Moradi A7 ; Alizadeh AM8 ; Khori V5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  6. 6. Department of Pharmacognosy, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Physiology, Medical School, Ardabil University of Medical Sciences, Ardabil, Iran
  8. 8. Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular Physiology Published:2019


Abstract

Acute myocardial infarction (AMI) is one of the leading causes of morbidity worldwide. Myocardial reperfusion is known as an effective therapeutic choice against AMI. However, reperfusion of blood flow induces ischemia/reperfusion (I/R) injury through different complex processes including ion accumulation, disruption of mitochondrial membrane potential, the formation of reactive oxygen species, and so forth. One of the processes that gets activated in response to I/R injury is autophagy. Indeed, autophagy acts as a “double-edged sword” in the pathology of myocardial I/R injury and there is a controversy about autophagy being beneficial or detrimental. On the basis of the autophagy effect and regulation on myocardial I/R injury, many studies targeted it as a therapeutic strategy. In this review, we discuss the role of autophagy in I/R injury and its targeting as a therapeutic strategy. © 2019 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4Th Edition)1, Autophagy (2021)
2. Regulatory Effects of Trimetazidine in Cardiac Ischemia/Reperfusion Injury, Naunyn-Schmiedeberg's Archives of Pharmacology (2023)
3. Autophagy Modulation in Breast Cancer Utilizing Nanomaterials and Nanoparticles, Frontiers in Oncology (2023)
4. Impact of Polyphenols on Heart Failure and Cardiac Hypertrophy: Clinical Effects and Molecular Mechanisms, Frontiers in Cardiovascular Medicine (2023)
5. Autophagy: A Challengeable Paradox in Cancer Treatment, Cancer Medicine (2023)
6. Mitochondria Signaling Pathways in Allergic Asthma, Journal of Investigative Medicine (2022)
7. Berberine Nanomicelles Attenuate Cirrhotic Cardiomyopathy in Rats: Possible Involvement of the No-Cgmp Signaling, Nanomedicine Journal (2020)
8. The Immunogenetics of Alopecia Areata, Advances in Experimental Medicine and Biology (2022)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Dehpour (5)
Hamid Reza Mirzaei (2)
Other Related Docs
9. Sumatriptan Protects Against Myocardial Ischaemia–Reperfusion Injury by Inhibition of Inflammation in Rat Model, Inflammopharmacology (2019)
10. Targeting Mammalian Target of Rapamycin: Prospects for the Treatment of Inflammatory Bowel Diseases, Current Medicinal Chemistry (2021)
11. Implications on the Therapeutic Potential of Statins Via Modulation of Autophagy, Oxidative Medicine and Cellular Longevity (2021)
12. Targeting Mtor With Curcumin: Therapeutic Implications for Complex Diseases, Inflammopharmacology (2025)
13. Epigenetic Regulation in Myocardial Infarction: Non-Coding Rnas and Exosomal Non-Coding Rnas, Frontiers in Cardiovascular Medicine (2022)
14. Unlocking the Therapeutic Potential of Autophagy Modulation by Natural Products in Tackling Non-Alcoholic Fatty Liver Disease, Phytotherapy Research (2025)
15. Autophagy, Its Mechanisms and Regulation: Implications in Neurodegenerative Diseases, Ageing Research Reviews (2017)
16. Contribution of Mammalian Target of Rapamycin in the Pathophysiology of Cirrhotic Cardiomyopathy, World Journal of Gastroenterology (2016)
17. Virus, Exosome, and Microrna: New Insights Into Autophagy, Advances in Experimental Medicine and Biology (2022)
18. The Potential of Targeting Autophagy-Related Non-Coding Rnas in the Treatment of Alzheimer’S and Parkinson’S Diseases, Cellular and Molecular Neurobiology (2024)
19. Regulation of Autophagy by Non-Coding Rnas in Human Glioblastoma, Medical Oncology (2024)
20. Autophagy Role As a Double-Edged Sword in Anesthesiology and Critical Care, Journal of Cellular and Molecular Anesthesia (2021)
21. Autophagy in Cancers Including Brain Tumors: Role of Micrornas, Cell Communication and Signaling (2020)
22. Doxorubicin-Induced Cardiotoxicity: An Overview on Pre-Clinical Therapeutic Approaches, Cardiovascular Toxicology (2022)
23. Synergistic Effect of Rapamycin and Metformin Against Germ Cell Apoptosis and Oxidative Stress After Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion in Rats, Biomedicine and Pharmacotherapy (2018)