Autophagy in Cancers Including Brain Tumors: Role of Micrornas Publisher Pubmed



Pourhanifeh MH¹ ; Mahjoubintehran M^{2, 3} ; Karimzadeh MR⁴ ; Mirzaei HR⁵ ; Razavi ZS^{6, 7} ; Sahebkar A^{8, 9} ; Hosseini N¹⁰ ; Mirzaei H¹¹ ; Hamblin MR¹² Show Affiliations
Source: Cell Communication and Signaling Published:2020

Abstract

Autophagy has a crucial role in many cancers, including brain tumors. Several types of endogenous molecules (e.g. microRNAs, AKT, PTEN, p53, EGFR, and NF1) can modulate the process of autophagy. Recently miRNAs (small non-coding RNAs) have been found to play a vital role in the regulation of different cellular and molecular processes, such as autophagy. Deregulation of these molecules is associated with the development and progression of different pathological conditions, including brain tumors. It was found that miRNAs are epigenetic regulators, which influence the level of proteins coded by the targeted mRNAs with any modification of the genetic sequences. It has been revealed that various miRNAs (e.g., miR-7-1-3p, miR-340, miR-17, miR-30a, miR-224-3p, and miR-93), as epigenetic regulators, can modulate autophagy pathways within brain tumors. A deeper understanding of the underlying molecular targets of miRNAs, and their function in autophagy pathways could contribute to the development of new treatment methods for patients with brain tumors. In this review, we summarize the various miRNAs, which are involved in regulating autophagy in brain tumors. Moreover, we highlight the role of miRNAs in autophagy-related pathways in different cancers. [MediaObject not available: see fulltext.] © 2020 The Author(s).