High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells

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High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells Publisher Pubmed

Panahi G¹ ; Pasalar P¹ ; Zare M² ; Rizzuto R³ ; Meshkani R¹

Source: Archives of Physiology and Biochemistry Published:2018

Abstract

Objective: The aim of this study was to investigate the effects of high glucose (HG) on inflammation in HepG2 cells. Methods: The molecular mechanisms linking HG to inflammation was assessed in HepG2 cells exposed to HG (33 mM). Results: The results showed that HG significantly enhanced TNF-α, IL-6 and PAI-1 expression in HepG2 cells. Increased expression of cytokines was accompanied by enhanced phosphorylation of JNK, P38, ERK and IKKα/IKKβ. In addition, JNK, ERK, P38 and NF-kB inhibitors could significantly attenuate HG-induced expression of TNF-α, IL-6 and PAI-1. Furthermore, HG could promote the generation of reactive oxygen species (ROS), while N-acetyl cysteine, a ROS scavenger, had an inhibitory effect on the expression of TNF-α, IL-6 and PAI-1 in HG-treated cells. Conclusions: Our results indicated that HG-induced inflammation is mediated through the generation of ROS and activation of the MAPKs and NF-kB signalling pathways in HepG2 cells. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Panahi G, et al.. "High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells." Archives of Physiology and Biochemistry, vol. 124, no. 5, 2018, pp. 468-474.
APA	Panahi G, Pasalar P, Zare M, Rizzuto R, Meshkani R (2018). High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells. Archives of Physiology and Biochemistry, 124(5), 468-474.
Chicago	Panahi G, Pasalar P, Zare M, Rizzuto R, Meshkani R. "High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells." Archives of Physiology and Biochemistry 124, no. 5 (2018): 468-474.
Harvard	Panahi G et al. (2018) 'High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells', Archives of Physiology and Biochemistry, 124(5), pp. 468-474.
Vancouver	Panahi G, Pasalar P, Zare M, Rizzuto R, Meshkani R. High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells. Archives of Physiology and Biochemistry. 2018;124(5):468-474.
BibTex	@article{ author = {Panahi G and Pasalar P and Zare M and Rizzuto R and Meshkani R}, title = {High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells}, journal = {Archives of Physiology and Biochemistry}, volume = {124}, number = {5}, pages = {468-474}, year = {2018} }
RIS	TY - JOUR AU - Panahi G AU - Pasalar P AU - Zare M AU - Rizzuto R AU - Meshkani R TI - High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells JO - Archives of Physiology and Biochemistry VL - 124 IS - 5 SP - 468 EP - 474 PY - 2018 ER -

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