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Certain Tsga10 Polymorphisms Are Not Associated With Male Infertility in Iranian Population Publisher



Soltani N1 ; Yazarlou F2 ; Akhondi MM3 ; Sobhani M4 ; Modarressi MH2 ; Ghafourifard S5
Authors
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Authors Affiliations
  1. 1. Molecular Medicine Department, Biotechnology Research Center, Pasteur institute of Iran, Tehran, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Reproductive Biotechnology Research Center, Avicenna research institute, ACECR, Tehran, Iran
  4. 4. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  5. 5. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gene Reports Published:2019


Abstract

Testis specific protein 10 (TSGA10) is expressed in normal adult testis and has been suggested to be involved in the normal function of sperms. Tsga10 expression has a role in the protection of spermatozoa and enhancement of male fertility. This gene has a number of single nucleotide polymorphisms (SNPs). In the current study, we genotyped rs3811553, rs200902126 and rs17852533 in 156 fertile men, 150 oligospermic and 150 azoospermic men using PCR-RFLP method. The genotyping showed that all assessed individuals were homozygote for wild type allele of both rs3811553 and rs200902126. In the case of the rs17852533, although we found the three genotypes in the studied individuals, there was no significant difference in distribution of these genotypes between the study groups. The current study shows insignificance of these SNPs in male infertility. However, future studies in larger sample sizes are needed to reach conclusive results. © 2019
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