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An Overview to Ankylosing Spondylitis and Spondyloarthropathies Publisher



Assadiasl S1 ; Soleimanifar N1
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Authors Affiliations
  1. 1. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors Published:2021


Abstract

Spondyloarthropathies (SpAs) are a debilitating group of chronic autoimmune diseases that affect a considerable proportion of young adults causing medical, social, and economical consequences. The prominent feature of SpAs is positive familial history and presence of HLA-B27 in most patients, which suggests genetic predisposing factors in disease pathogenesis. Ankylosing Spondylitis (AS), being the most prevalent and severe form of SpAs, is generally characterized by inflammatory low back pain accompanied by radiological findings of sacroiliitis. Despite all radiological and laboratory advancements, the complicated manifestations of AS urges for multi-factorial diagnostic criteria evolved during recent years for efficient detection and follow-up of the patients. According to the inflammatory base of SpAs, various anti-inflammatory medications have been used for treating the patients ranging from nonsteroidal anti-inflammatory drugs to Disease-modifying anti-rheumatic drugs, including synthetic and biologic agents. In the present chapter, we provide a general overview of epidemiologic, diagnostic, pathophysiologic, and therapeutic aspects of Spondyloarthropathies. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
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