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The Impact of Malignancy on the Risk of Venous Thromboembolism in Pregnant Women: A Systematic Review Publisher



Vaezi A1 ; Rafiei SKS2 ; Amiri B3 ; Rezvanimehr A4, 5 ; Naji Abhary M6 ; Mahdavi P2 ; Abbasalizadeh M7, 8 ; Yavari G9 ; Sattari MS10 ; Kheirandish A11 ; Erabi G12 ; Zadeh FV13 ; Rasekh F14 ; Pormehryabandeh A15 Show All Authors
Authors
  1. Vaezi A1
  2. Rafiei SKS2
  3. Amiri B3
  4. Rezvanimehr A4, 5
  5. Naji Abhary M6
  6. Mahdavi P2
  7. Abbasalizadeh M7, 8
  8. Yavari G9
  9. Sattari MS10
  10. Kheirandish A11
  11. Erabi G12
  12. Zadeh FV13
  13. Rasekh F14
  14. Pormehryabandeh A15
  15. Mohagheghi SZ16
  16. Zaraj H17
  17. Abdi A18
  18. Dadkhah PA19
  19. Deravi N2
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  6. 6. Department of Midwifery, School of Nursing & Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Research Center for Evidence-Based Medicine, Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  10. 10. School of Medical Sciences, Azad Sari University of Medical Sciences, Mazandaran, Iran
  11. 11. Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
  12. 12. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  13. 13. Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  14. 14. Student Research Committee, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran
  15. 15. Hormozgan Health Institute, Hormozgan University of Medical Science, Bandar Abbas, Iran
  16. 16. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  17. 17. Tehran University-Caspian Campus, Tehran, Iran
  18. 18. Student Research Committee, School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  19. 19. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Health Science Reports Published:2025


Abstract

Background and Aims: Venous thromboembolism (VTE) is a distinct malignancy complication that raises the risk of demise in cancer patients by up to thrice. However, pregnant females have a 4–5 times greater chance of getting VTE than nonpregnant women. The current systematic review aimed to elucidate the impact of malignancy on the risk of VTE in pregnant females. Methods: We carried out a systematic search in multiple databases, including PubMed (Medline), Google Scholar, and Scopus, up to January 2023. Finally, 441 related articles were extracted from the databases. After screening the title, abstract, and full text, seven articles were included in the study. Results: Seven studies (six cohorts and one cross-sectional) with 58,854,195 pregnant females (22,396 cancer patients) were included. These studies were done in the United States of America, Canada, Brazil, and Denmark. All of the studies except one study demonstrated that cancer in pregnant patients increased the risk of deep vein thrombosis (DVT). The risk of VTE prevalence in pregnant females with a record of malignancy was significantly higher than in free cancer groups, and the highest aOR was correlated to myeloid leukemia. Conclusions: Evidence in this systematic review showed that pregnant women with malignancy are more susceptible to VTE and other coagulation disorders. Physicians and health policymakers should be of high vigilance to pregnancy-associated VTE, especially in women who have cancer. © 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
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