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Clear Cell Carcinoma of the Ovary and Venous Thromboembolism: A Systematic Review and Meta-Analysis Publisher Pubmed



Didar H1 ; Farzaneh F1 ; Najafiarab H1 ; Namakin K2 ; Gohari K3 ; Sheidaei A4 ; Ramezani S5
Authors
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Authors Affiliations
  1. 1. Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Source: Current Medical Research and Opinion Published:2023


Abstract

Objectives: As the second most common subtype of Epithelial ovarian cancers (EOCs), ovarian clear cell carcinoma (OCCC) is associated with a high rate of cancer-associated thrombosis. Previous studies revealed the wide range prevalence (6–42%) of venous thromboembolism (VTE) among OCCC patients. This study aimed to determine the prevalence of VTE among OCCC patients as well as factors affecting it. Methods: PubMed, Scopus, Embase, and Cochrane Library databases were searched up to December 12th, 2022. Studies reporting venous thromboembolic events in women with clear cell carcinoma of the ovary were included. Demographic data, clinical, and paraclinical features of the patients were independently extracted by two reviewers. Results: Out of the 2254 records, 43 studies were processed for final review. The qualified studies involved 573 VTE cases among 2965 patients with OCCC. The pooled prevalence of VTE among OCCC patients was 21.32% (95%CI=(17.38–25.87)). Most VTE events were reported in Japanese women (26.15%), followed by Americans (24.41%) and UK (21.57%), and Chinese (13.61%) women. VTE was more common in patients with advanced stages (37.79%) compared to those with early stages of the disease (16.54%). Conclusions: Ovarian clear cell carcinoma is associated with a high rate of cancer-associated thrombosis. VTE events in OCCC patients were higher in advanced stages and Japanese women. © 2023 Informa UK Limited, trading as Taylor & Francis Group.