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Will Nanotechnology Bring New Hope for Gene Delivery? Publisher Pubmed



Wong JKL1 ; Mohseni R2 ; Hamidieh AA2 ; Maclaren RE3 ; Habib N4 ; Seifalian AM5
Authors
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Authors Affiliations
  1. 1. School of Medicine, Imperial College London, London, United Kingdom
  2. 2. Hematology-Oncology and Stem Cell Transplantation Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
  4. 4. Faculty of Medicine, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
  5. 5. Nanotechnology and Regenerative Medicine Centre (Ltd), The London Innovation BioScience Centre, London, United Kingdom

Source: Trends in Biotechnology Published:2017


Abstract

The high mortality rates of cancer patients receiving standard treatments emphasize the crucial need for alternative treatments. One promising strategy is to use organic nanoparticles (NPs) for gene delivery. Although multifunctional NPs theoretically have many desirable properties as gene vectors, there are several practical barriers to successful gene delivery. In this review we discuss the properties of NPs and overview in vitro and preclinical studies of organic NPs over the past 5 years. The results of recent clinical trials suggest that the NP field holds significant promise. The annual market value for successful gene delivery could exceed US$30 billion, and this will encourage researchers to study the application of NPs to therapeutic gene delivery. © 2016 Elsevier Ltd
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