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Nano-Particles’ Benefits for Colon Cancer Effective Therapy: A Review of Recent Advancements and Clinical Trials Publisher



Faraji G1 ; Moeini P2 ; Rajabi Torkamani A3 ; Shafiee H1 ; Nazemalhosseini Mojarad E4
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Authors Affiliations
  1. 1. Department of Molecular and Cellular Sciences, Faculty of Advanced Sciences and Technology, Islamic Azad University, Tehran Medical Sciences, Tehran, Iran
  2. 2. Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain
  3. 3. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Gastroenterology and Liver Disease Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2024


Abstract

A variety of fascinating nanocarriers have reportedly been used and highlighted as novel drug delivery system in human colorectal cancer (CRC) treatment. In this context, significant progress has been achieved in the last few years and a great deal of promising NPs application has been reported as well. According to the literature reviews, the application of different types of NPs improves the efficacy, stability and selectivity of anti-colon cancer drugs. Moreover, the outcome of in vitro and in vivo experiments, also conducted preclinical and clinical investigations, has not only pushed the boundaries of knowledge but also revealed the favorable therapeutic benefits of NPs in CRC therapy more than before. Thus, scientists conclude that it is not surprising if NPs play a crucial role in CRC treatment in the near future. The present review gathers the most recent knowledge of the field, and also addresses a summary of the advancements and clinical trials conducted so far. The authors hope that the present review will provide comprehensive information about the up-to-date results of the recently conducted investigations for those who are willing to read everything at a glance. © 2023 Taylor & Francis Group, LLC.
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