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Liquid Biopsy in Pediatric Urogenital Tumors Publisher



Ghahestani SM1 ; Yahyazadeh SR2 ; Amirzargar H3 ; Tavoosian A3 ; Reis LO4, 5
Authors
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Authors Affiliations
  1. 1. Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. UroScience and Department of Surgery (Urology), School of Medical Sciences, University of Campinas, Unicamp, Sao Paulo, Campinas, Brazil
  5. 5. Pontifical Catholic University of Campinas, PUC-Campinas, Sao Paulo, Campinas, Brazil

Source: Liquid Biopsy in Urogenital Cancers and its Clinical Utility Published:2022


Abstract

Cell-free DNA profiling by patient blood is developing as a noninvasive complementary technique for cancer genomic characterization. Since these liquid biopsies will soon be combined into clinical trial protocols for pediatric cancer treatment, clinicians would be up-to-date about potential applications and benefits but also weaknesses and potential drawbacks. Small retrospective studies comparing genetic alterations distinguished in liquid biopsies with tumor biopsies for pediatric solid tumor types are hopeful. Molecular detection of tumor markers in ctDNA could be used for earlier therapy response monitoring and residual disease detection as well as enabling detection of pathognomonic and therapeutically relevant genomic alterations. © 2022 Elsevier Inc. All rights reserved.
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