Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors

Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors Publisher

Aghamir SMK¹ ; Heshmat R² ; Ebrahimi M³ ; Khatami F¹

Show Affiliations

1. Urology Research Center (URC), Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Internal Medicine, Faculty of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Epigenetics Insights Published:2020

Abstract

Blood test is a kind of liquid biopsy that checks cancer cells or cancer nucleic acids circulating freely from cells in the blood. A liquid biopsy may be used to distinguish cancer at early stages and it could be a game-changer for both cancer diagnosis and prognosis strategies. Liquid biopsy tests consider several tumor components, such as DNA, RNA, proteins, and the tiny vesicles originating from tumor cells. Actually, liquid biopsy signifies the genetic alterations of tumors through nucleic acids or cells in various body fluids, including blood, urine, cerebrospinal fluid, or saliva in a noninvasive manner. In this review, we present an overall description of liquid biopsy in which circulating tumor cells, cell-free nucleic acids, exosomes, and extrachromosomal circular DNA are included. © The Author(s) 2020.

Related Docs

View other Related Docs

1. Liquid Biopsy in Thyroid Cancer: New Insight, International Journal of Hematology-Oncology and Stem Cell Research (2018)

2. Potential Theranostics of Circulating Tumor Cells and Tumor-Derived Exosomes Application in Colorectal Cancer, Cancer Cell International (2020)

3. Circulating Tumor Dna (Ctdna) in the Era of Personalized Cancer Therapy, Journal of Diabetes and Metabolic Disorders (2018)

4. The Presence of Tumor Extrachomosomal Circular Dna (Ecdna) As a Component of Liquid Biopsy in Blood, Medical Hypotheses (2018)

5. Overview of Liquid Biopsy, Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)

6. Liquid Biopsy in Kidney Tumor, Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)

7. Liquid Biopsy As a Minimally Invasive Source of Thyroid Cancer Genetic and Epigenetic Alterations, International Journal of Molecular and Cellular Medicine (2019)

8. The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review, Acta Medica Iranica (2017)

Experts (# of related papers)

View all Related Experts

Seyed Mohammad Tavangar (16)

Bagher Larijani (9)

Other Related Docs

9. Hypermethylated Rassf1 and Slc5a8 Promoters Alongside Brafv600e Mutation As Biomarkers for Papillary Thyroid Carcinoma, Journal of Cellular Physiology (2020)

10. Prediction of the Treatment Response in Ovarian Cancer: A Ctdna Approach, Journal of Ovarian Research (2020)

11. Prognostic and Therapeutic Significance of Circulating Tumor Cells in Patients With Lung Cancer, Cellular Oncology (2020)

12. Exosomes in Cancer Liquid Biopsy: A Focus on Breast Cancer, Molecular Therapy Nucleic Acids (2018)

13. Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications, Current Medicinal Chemistry (2021)

14. Human Uterine Fluid Lavage-Derived Extracellular Vesicle Isolation: A Comparative Study for Minimally Invasive Endometrial Receptivity Assessment, Reproductive BioMedicine Online (2022)

15. Paper-Based Biosensors As Point-Of-Care Diagnostic Devices for the Detection of Cancers: A Review of Innovative Techniques and Clinical Applications, Frontiers in Oncology (2023)

16. Investigating the Role of Circulating Tumor Cells in Gastric Cancer: A Comprehensive Systematic Review and Meta-Analysis, Clinical and Experimental Medicine (2024)

17. Circulating Ctdna Methylation Quantification of Two Dna Methyl Transferases in Papillary Thyroid Carcinoma, Journal of Cellular Biochemistry (2019)

18. A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment, Pathology Research and Practice (2023)

19. Low Expression of Talin1 Is Associated With Advanced Pathological Features in Colorectal Cancer Patients, Scientific Reports (2020)

20. Common Molecular Markers Between Circulating Tumor Cells and Blood Exosomes in Colorectal Cancer: A Systematic and Analytical Review, Cancer Management and Research (2019)

21. Mesenchymal Stem Cell-Derived Exosomes: A New Therapeutic Approach to Osteoarthritis?, Stem Cell Research and Therapy (2019)

22. Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions, Critical Reviews in Oncology/Hematology (2021)

23. Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma, Iranian Journal of Pathology (2019)

24. Breast Cancer Diagnostics by the Intelligent Analysis of White Blood Cells’ Interaction With Target Cancer Cells Using Convolutional Neural Networks, Microchemical Journal (2024)

25. Tumor-Educated Platelets, Clinica Chimica Acta (2024)

26. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)

27. Cpg Islands Hypermethylatioin the Promoter Region of Gstp1 Gene in Cell-Free Dna As a Noninvasive Biomarker for Detecting Prostate Cancer, Biochemical and Cellular Archives (2016)

28. A Micropillar Array-Based Microfluidic Chip for Label-Free Separation of Circulating Tumor Cells: The Best Micropillar Geometry?, Journal of Advanced Research (2023)

29. Minimal Information for Studies of Extracellular Vesicles (Misev2023): From Basic to Advanced Approaches, Journal of Extracellular Vesicles (2024)

30. Methylation in Colorectal Cancer, Epigenetics Territory and Cancer (2015)

31. Emerging Roles of Exosomal Mirnas in Breast Cancer Drug Resistance, IUBMB Life (2019)

32. Antigenic Targets of Car T Cell Therapy. a Retrospective View on Clinical Trials, Experimental Cell Research (2018)

33. Microchips and Their Significance in Isolation of Circulating Tumor Cells and Monitoring of Cancers, Asian Pacific Journal of Cancer Prevention (2016)

34. Multiple Endocrine Neoplasia Syndromes From Genetic and Epigenetic Perspectives, Biomarker Insights (2018)

35. Circulating Tumor Braf Mutation and Personalized Thyroid Cancer Treatment, Asian Pacific Journal of Cancer Prevention (2017)

36. Ghsr Dna Hypermethylation Is a New Epigenetic Biomarker for Gastric Adenocarcinoma and Beyond, Journal of Cellular Physiology (2019)

37. Adrenal Collision Tumor Composed of Pheochromocytoma and Diffuse Large B-Cell Lymphoma: A Case Report, International Journal of Hematology-Oncology and Stem Cell Research (2018)

38. Immunomagnetic Isolation of Her2-Positive Breast Cancer Cells Using a Microfluidic Device, ACS Omega (2023)

39. Recent Advances in the Roles of Exosomal Micrornas (Exomirs) In Hematologic Neoplasms: Pathogenesis, Diagnosis, and Treatment, Cell Communication and Signaling (2023)

40. A State-Of-The-Art Review of the Recent Advances in Exosome Isolation and Detection Methods in Viral Infection, Virology Journal (2024)

41. Prognostic Value of Lactate Dehydrogenase in Metastatic Prostate Cancer: A Systematic Review and Meta-Analysis, Clinical Genitourinary Cancer (2019)

42. Liquid Biopsy in Bladder Tumors, Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)

43. The Tumor Microenvironment's Gambit: Exosomal Pawns on the Board of Head and Neck Cancer, Biochimica et Biophysica Acta - Reviews on Cancer (2024)

44. The Impact of Succinate Dehydrogenase Gene (Sdh) Mutations in Renal Cell Carcinoma (Rcc): A Systematic Review, OncoTargets and Therapy (2019)

45. Applications of Innovation Technologies for Personalized Cancer Medicine: Stem Cells and Gene-Editing Tools, ACS Pharmacology and Translational Science (2023)

46. Emerging Role of Micrornas As Liquid Biopsy Biomarkers in Lung Cancer: A Review, Acta Medica Iranica (2021)

47. Applications of Single-Cell Omics for Chimeric Antigen Receptor T Cell Therapy, Immunology (2024)

48. Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells, Clinical and Experimental Medicine (2025)

49. Recent Advances in Non-Small Cell Lung Cancer Targeted Therapy; an Update Review, Cancer Cell International (2023)

50. Tumor-Derived Exosomes: The Next Generation of Promising Cell-Free Vaccines in Cancer Immunotherapy, OncoImmunology (2020)

Style	Citing Format
MLA	Aghamir SMK, et al.. "Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors." Epigenetics Insights, vol. 13, no. , 2020, pp. -.
APA	Aghamir SMK, Heshmat R, Ebrahimi M, Khatami F (2020). Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors. Epigenetics Insights, 13(), -.
Chicago	Aghamir SMK, Heshmat R, Ebrahimi M, Khatami F. "Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors." Epigenetics Insights 13, no. (2020): -.
Harvard	Aghamir SMK et al. (2020) 'Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors', Epigenetics Insights, 13(), pp. -.
Vancouver	Aghamir SMK, Heshmat R, Ebrahimi M, Khatami F. Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors. Epigenetics Insights. 2020;13():-.
BibTex	@article{ author = {Aghamir SMK and Heshmat R and Ebrahimi M and Khatami F}, title = {Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors}, journal = {Epigenetics Insights}, volume = {13}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Aghamir SMK AU - Heshmat R AU - Ebrahimi M AU - Khatami F TI - Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors JO - Epigenetics Insights VL - 13 IS - SP - EP - PY - 2020 ER -