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Car T Cells and Metabolic Programming: A Review Publisher



S Hatami SHEKOUFEH ; F Kazemi FATEMEH ; P Doroudgar PARISA ; S Shomeil Shushtari SAHAR ; Mr Atashzar Mohammad REZA
Authors

Source: Medical Immunology (Russia) Published:2025


Abstract

Chimeric antigen receptor (CAR) T cell therapy shown a promising treatment for haematological malignancies. Although it has successful achievement in hematological malignancies, there are major challenges that remain to be resolved to the broad application. To overcome these obstacles, changes in metabolism during the preparation of CAR T cells increase their therapeutic specificity and potency. Therefore, generation of CAR T cells with manipulated metabolic pathways could beneficially enhance antitumor immunity. Here in this review we summarize the latest advances and new strategies that have been developed to improve the metabolic fitness and antitumor activity of CAR T cells products. © 2025 Elsevier B.V., All rights reserved.
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