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An Updated Overview of the Application of Car-T Cell Therapy in Neurological Diseases Publisher



Shahabifard H1 ; Zarei M2 ; Kookli K3 ; Esmalian Afyouni N4 ; Soltani N5 ; Maghsoodi S6 ; Adili A7 ; Mahmoudi J1 ; Shomali N8 ; Sandoghchian Shotorbani S8
Authors
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Authors Affiliations
  1. 1. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. International Campus, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Laboratory Sciences, Faculty of Paramedical Sciences, Kurdistan University of Medical Sciences (MUK), Sanandaj, Iran
  7. 7. Department of Oncology, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Biotechnology Progress Published:2023


Abstract

Genetically modified immune cells, especially CAR-T cells, have captured the attention of scientists over the past 10 years. In the fight against cancer, these cells have a special place. Treatment for hematological cancers, autoimmune disorders, and cancers must include CAR-T cell therapy. Determining the therapeutic targets, side effects, and use of CAR-T cells in neurological disorders, including cancer and neurodegenerative diseases, is the goal of this study. Due to advancements in genetic engineering, CAR-T cells have become crucial in treating some neurological disorders. CAR-T cells have demonstrated a positive role in treating neurological cancers like Glioblastoma and Neuroblastoma due to their ability to cross the blood–brain barrier and use diverse targets. However, CAR-T cell therapy for MS diseases is being researched and could be a potential treatment option. This study aimed to access the most recent studies and scientific articles in the field of CAR-T cells in neurological diseases and/or disorders. © 2023 American Institute of Chemical Engineers.
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