Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies

Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies Publisher

Khashayar P¹ ; Rad FF² ; Tabatabaeimalazy O^{2, 3} ; Golabchi SM² ; Khashayar P¹ ; Mohammadi M⁵ ; Ebrahimpour S⁵ ; Larijani B³

Show Affiliations

1. School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom
2. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Chemistry, Ghent University, Krijgslaan 281-S12, Gent, 9000, Belgium
5. Department of Clinical Pharmacy, School of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran

Source: Diabetology and Metabolic Syndrome Published:2024

Abstract

Background: No clear consensus exists regarding the safest anti-diabetic drugs with the least adverse events on bone health. This umbrella systematic review therefore aims to assess the published meta-analysis studies of randomized controlled trials (RCTs) conducted in this field. Methods: All relevant meta-analysis studies of RCTs assessing the effects of anti-diabetic agents on bone health in patients with diabetes mellitus (DM) were collected in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). English articles published until 15 March 2023 were collected through the search of Cochrane Library, Scopus, ISI Web of Sciences, PubMed, and Embase using the terms “Diabetes mellitus”, “anti-diabetic drugs”, “Bone biomarker”, “Bone fracture, “Bone mineral density” and their equivalents. The methodological and evidence quality assessments were performed for all included studies. Results: From among 2220 potentially eligible studies, 71 meta-analyses on diabetic patients were included. Sodium-glucose cotransporter-2 inhibitors (SGLT-is) showed no or equivalent effect on the risk of fracture. Dipeptidyl peptidase-4 inhibitors (DPP-4is) and Glucagon-like peptide-1 receptor agonists (GLP-1Ras) were reported to have controversial effects on bone fracture, with some RCTs pointing out the bone protective effects of certain members of these two medication classes. Thiazolidinediones (TZDs) were linked with increased fracture risk as well as higher concentrations of C-terminal telopeptide of type I collagen (CTx), a bone resorption marker. Conclusion: The present systematic umbrella review observed varied results on the association between the use of anti-diabetic drugs and DM-related fracture risk. The clinical efficacy of various anti-diabetic drugs, therefore, should be weighed against their risks and benefits in each patient. © The Author(s) 2024.

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Style	Citing Format
MLA	Khashayar P, et al.. "Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies." Diabetology and Metabolic Syndrome, vol. 16, no. 1, 2024, pp. -.
APA	Khashayar P, Rad FF, Tabatabaeimalazy O, Golabchi SM, Khashayar P, Mohammadi M, Ebrahimpour S, Larijani B (2024). Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies. Diabetology and Metabolic Syndrome, 16(1), -.
Chicago	Khashayar P, Rad FF, Tabatabaeimalazy O, Golabchi SM, Khashayar P, Mohammadi M, Ebrahimpour S, Larijani B. "Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies." Diabetology and Metabolic Syndrome 16, no. 1 (2024): -.
Harvard	Khashayar P et al. (2024) 'Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies', Diabetology and Metabolic Syndrome, 16(1), pp. -.
Vancouver	Khashayar P, Rad FF, Tabatabaeimalazy O, Golabchi SM, Khashayar P, Mohammadi M, et al.. Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies. Diabetology and Metabolic Syndrome. 2024;16(1):-.
BibTex	@article{ author = {Khashayar P and Rad FF and Tabatabaeimalazy O and Golabchi SM and Khashayar P and Mohammadi M and Ebrahimpour S and Larijani B}, title = {Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies}, journal = {Diabetology and Metabolic Syndrome}, volume = {16}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Khashayar P AU - Rad FF AU - Tabatabaeimalazy O AU - Golabchi SM AU - Khashayar P AU - Mohammadi M AU - Ebrahimpour S AU - Larijani B TI - Hypoglycemic Agents and Bone Health; an Umbrella Systematic Review of the Clinical Trials’ Meta-Analysis Studies JO - Diabetology and Metabolic Syndrome VL - 16 IS - 1 SP - EP - PY - 2024 ER -

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