Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Mechanisms Involved in Altered Bone Metabolism in Diabetes: A Narrative Review Publisher



Ghodsi M1 ; Larijani B2 ; Keshtkar AA3 ; Nasliesfahani E1 ; Alatab S4 ; Mohajeritehrani MR2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Tehran University of Medical Sciences (TUMS), Diabetes Research Center (DRC), Endocrinology and Metabolism Research Institute (EMRI), Tehran, Iran
  2. 2. Tehran University of Medical Sciences (TUMS), Endocrinology and Metabolism Research Center (EMRC), Endocrinology and Metabolism Resarch Institute (EMRI), Tehran, Iran
  3. 3. Tehran University of Medical Sciences (TUMS), Department of Health Sciences Education Development, School of Public Health (SPH), Tehran, Iran
  4. 4. Urology Research Center (URC), Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2016


Abstract

Many studies have shown that change in metabolism caused by diabetes can influence the bone metabolism in a way that quality and strength of bone is decreased. A 6 times and 2 times increased risk of fracture is reported in patients with type 1 and type 2 diabetes, respectively. There are several mechanisms by which diabetes can affect the bone. The fact that some of these mechanisms are acting in opposite ways opens the door for debate on pathways by which diabetes affects the bones. On the other hand, bone is not a simple organ that only get influence from other organs, but it is an endocrine organ that by secreting the agents such as osteocalcin, adiponectin and visfatin which can affect the insulin sensitivity and metabolism. In this paper we tried to briefly assess the latest finding in this matter. © 2016 The Author(s).
Related Docs
View other Related Docs
1. The Effects of Weight Loss Approaches on Bone Mineral Density in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Osteoporosis International (2016)
2. Association Between Serum Osteocalcin and Body Mass Index: A Systematic Review and Meta-Analysis, Endocrine (2017)
3. Osteocalcin Is a Predictor for Diabetes Mellitus in Postmenopausal Women and Correlated With Oral Intake of Vitamin K, Mediterranean Journal of Nutrition and Metabolism (2015)
4. Suitable Bone Markers Assessing Bone Status in Patients With Both Coronary Artery Disease and Diabetes, Journal of Diabetes and Metabolic Disorders (2016)
5. Bone Structure and Turnover in Postmenopausal Women With Type 2 Diabetes Mellitus, Menopause (2016)
6. The Association Between Osteocalcin and C-Reactive Protein; a Relation of Bone With Inflammation: A Systematic Review and Meta-Analysis, Hormone and Metabolic Research (2019)
7. Diabetes Mellitus and Osteoporosis Correlation: Challenges and Hopes, Current Diabetes Reviews (2020)
8. Effects of Coenzyme Q10 Supplementation on Serum Adiponectin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Drug Therapy (2020)
Experts (# of related papers)
View all Related Experts
Bagher Larijani (6)
Sakineh Shab-Bidar (4)
Other Related Docs
9. Molecular and Cellular Mechanisms Linking Inflammation to Insulin Resistance and Β-Cell Dysfunction, Translational Research (2016)
10. Role of Vitamin D and Vitamin D Receptor Gene Polymorphisms on Residual Beta Cell Function in Children With Type 1 Diabetes Mellitus, Pharmacological Reports (2019)
11. Vitamin D Receptor Gene Polymorphisms and Susceptibility to Type 2 Diabetes: Evidence From a Meta-Regression and Meta-Analysis Based on 47 Studies, Journal of Diabetes and Metabolic Disorders (2021)
12. Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies, BioMed Research International (2018)
13. Relationship Between Leptin and Adiponectin Concentrations in Plasma and Femoral and Spinal Bone Mineral Density in Spinal Cord-Injured Individuals, Spine Journal (2015)
14. Immunomodulatory Actions of Vitamin D in Various Immune-Related Disorders: A Comprehensive Review, Frontiers in Immunology (2023)
15. Association Between Liver Fibrosis and Osteoporosis in Adults Aged 50 and Older: Insights From the Bushehr Elderly Health Program, Journal of Diabetes and Metabolic Disorders (2025)
16. Beneficial Effects of N-3 Polyunsaturated Fatty Acids on Adiponectin Levels and Adipor Gene Expression in Patients With Type 2 Diabetes Mellitus: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial, Archives of Medical Science (2017)
17. Asthma and Vitamin D Deficiency: Occurrence, Immune Mechanisms, and New Perspectives, Journal of Immunology Research (2022)
18. Association Between Uncoupling Protein 2, Adiponectin and Resting Energy Expenditure in Obese Women With Normal and Low Resting Energy Expenditure, Gynecological Endocrinology (2018)
19. Molecular Evidence of Role of Vitamin D Deficiency in Various Extraskeletal Diseases, Journal of Cellular Biochemistry (2019)
20. Association of Vitamin D Receptor Gene Polymorphism With the Occurrence of Low Bone Density, Osteopenia, and Osteoporosis in Patients With Type 2 Diabetes, Journal of Diabetes and Metabolic Disorders (2021)
21. Metformin Use and Risk of Fracture: A Systematic Review and Meta-Analysis of Observational Studies, Osteoporosis International (2019)
22. Inflammatory Cytokines and Type 2 Diabetes, Koomesh (2020)
23. Vitamin D Receptor Gene Polymorphisms, Metabolic Syndrome, and Type 2 Diabetes in Iranian Subjects: No Association With Observed Snps, International Journal for Vitamin and Nutrition Research (2016)
24. Immunomodulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis Mice, a Multiple Sclerosis Animal Model, Iranian Journal of Allergy# Asthma and Immunology (2023)
25. The Effects of Vitamin D, K and Calcium Co-Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Overweight Type 2 Diabetic Patients With Chd, British Journal of Nutrition (2016)
26. Effects of Parenteral Vitamin D on the Biomarkers of the Endothelial Function in Patients With Type 2 Diabetes and Ischemic Heart Disease: A Randomized Clinical Trial, Iranian Journal of Pharmaceutical Research (2018)
27. Vitamin D Receptor Gene Polymorphisms and the Risk of Metabolic Syndrome (Mets): A Meta-Analysis, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)
28. Visfatin in Obese Children and Adolescents and Its Association With Insulin Resistance and Metabolic Syndrome, Scandinavian Journal of Clinical and Laboratory Investigation (2015)
29. Harnessing the Fundamental Roles of Vitamins: The Potent Anti-Oxidants in Longevity, Biogerontology (2025)
30. Effect of Vitamin D Deficiency on Coronary Artery Stenosis, Iranian Heart Journal (2015)
31. Maternal Vitamin D Status and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Prospective Cohort Studies, Clinical Nutrition (2021)
32. Vitamin D and Diabetic Nephropathy: A Systematic Review and Meta-Analysis, Nutrition (2015)