Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparative Study of the Effect of Various Bariatric Surgery Methods on Liver Enzymes and Grading of Nonalcoholic Fatty Liver Based on Ultrasound Scans in Children and Adults Publisher



Yousefi A1 ; Safari F2 ; Pazouki A3 ; Pourzahabi Z4 ; Riazi S3 ; Talebi A5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Center of Excellence for Minimally Invasive Surgery Training, Iran University of Medical Sciences, Center of Excellence of European Branch of International Federation for Surgery of Obesity, Tehran, Iran
  4. 4. Pediatric Chronic Kidney Disease Research Center, Department of Pediatric Nephrology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Colorectal Research Center, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

Source: World Journal of Laparoscopic Surgery Published:2022


Abstract

Introduction: Bariatric surgery is one of the most effective treatments for patients with morbid obesity. Rapid weight loss can accelerate thprocess of fibrosis, and weight loss alone can improve the process of steatohepatitis. The conflict has confused the effect of these surgeries othe severity of the fatty liver disease. This retrospective study aimed to compare the effects of different types of bariatric surgery on the gradinand severity of the nonalcoholic fatty liver disease (NAFLD). Materials and methods: Using the National Obesity Surgery Database, data were extracted from 900 patients with a body mass index (BMI) above 35 who underwent sleeve, classic bypass, or mini-bypass surgery or who did not undergo surgery for any reason. Body mass index, aspartate transaminase (AST), alanine transaminase (ALT), NAFLD fibrosis score, and liver ultrasound were evaluated before and after surgery in four different groups. Results: All three surgical procedures effectively reduced BMI. Among the various surgical procedures, the rate of BMI reduction was significantly higher in the mini-gastric bypass procedure than in the other two methods. The reduction of AST and ALT was significant in all three surgical methods compared to the nonsurgical group, with the highest reduction in sleeve surgery. Fatty liver based on ultrasound in the nonsurgical group in the second time got worse but improved significantly in all the operated groups, and all these changes including the development of fatty liver in the nonsurgical group and its improvement in the operated groups were significant (p <0.05) and NAFLD fibrosis score (NFS) decreased in all groups. This reduction was small and insignificant for the nonsurgical group while it was significant in the three operated groups. © The Author(s). 2022.
Related Docs
1. Changes in Serum Albumin and Liver Enzymes Following Three Different Types of Bariatric Surgery: Six-Month Follow-Up. a Retrospective Cohort Study, Sao Paulo Medical Journal (2021)
2. Synbiotic Supplementation in Lean Patients With Non-Alcoholic Fatty Liver Disease: A Pilot, Randomised, Double-Blind, Placebo-Controlled, Clinical Trial, British Journal of Nutrition (2017)
Experts (# of related papers)
View all Related Experts
Reza Malekzadeh (1)
Hasti Ansar (1)