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Metabolically Healthy and Unhealthy Obesity and the Progression of Liver Fibrosis: A Cross-Sectional Study Publisher Pubmed



Tutunchi H1 ; Naeini F2 ; Ebrahimimameghani M3 ; Najafipour F4 ; Mobasseri M4 ; Ostadrahimi A1
Authors
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Authors Affiliations
  1. 1. Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran university of medical science, Tehran, Iran
  3. 3. Social Determinant of Health Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Clinics and Research in Hepatology and Gastroenterology Published:2021


Abstract

Background: The development of liver fibrosis is the most important predictor of adverse outcomes in patients with non-alcoholic fatty liver disease (NAFLD). Little is known regarding the risk factors for the progression of NAFLD to liver fibrosis. The present cross-sectional study aimed to examine the association of liver fibrosis with metabolically healthy and unhealthy obesity among patients with NAFLD. Methods: The severity of fatty liver was examined using ultrasonography. We used the NAFLD fibrosis score to determine the severity of liver fibrosis. Anthropometric indices, physical activity, and body composition were assessed. Blood samples were collected to determine serum metabolic parameters. Participants without any component of metabolic syndrome and homeostasis model assessment of insulin resistance (HOMA-IR) <2.5 were considered as metabolically healthy. To examine the association of liver fibrosis with metabolically healthy and unhealthy obesity, multivariable-adjusted odds ratios (ORs) were applied. Results: The current study included a total of 246 patients with NAFLD and low probability of fibrosis. 46.3% of subjects were metabolically healthy and 53.7% were metabolically unhealthy. Among metabolically healthy subjects, multivariable‐adjusted ORs (CIs) for worsening of NAFLD fibrosis score comparing body mass indexes (BMIs) 23.0–24.9, 25–29.9, and ≥30 with a BMI=18.5–22.9 kg/m2 were 1.28 (1.09‐1.56), 1.99 (1.49‐2.63), and 3.96 (2.89‐4.71), respectively. The corresponding ORs (95% CIs) among metabolically unhealthy subjects were 1.39 (1.32‐1.64), 2.27 (1.98‐2.49), and 4.11 (3.12‐4.93), respectively. Moreover, in both healthy and unhealthy individuals, higher percentages of body fat and waist circumference were significantly associated with worsening of NAFLD fibrosis score. Conclusion: Excess body fat contributes to the progression of liver fibrosis regardless of metabolic health status. © 2021 Elsevier Masson SAS
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