Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Epidemiology and Socioeconomic Correlates of Brain and Central Nervous System Cancers in Asia in 2020 and Their Projection to 2040 Publisher Pubmed



Mousavi SE1, 2 ; Seyedmirzaei H3, 4 ; Shahrokhi Nejad S5 ; Nejadghaderi SA6, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Community Medicine, Social Determinants of Health Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Interdisciplinary Neuroscience Research Program (INRP), Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Systematic Review and Meta‑analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Scientific Reports Published:2024


Abstract

Brain and central nervous system (CNS) cancers constitute a heterogeneous group of cancers with poor 5-year survival rates. We aimed to report the epidemiology of brain and CNS cancers in Asia in 2020 and their projections up to 2040 by age, sex, and country, as well as their correlation with socioeconomic status. We extracted data from the 2020 Global Cancer Observatory (GLOBOCAN). Numbers, age-standardized incidence rates (ASIRs) and mortality rates (ASMRs), 5-year prevalent cases and rates, mortality-to-incidence ratios (MIRs), and crude rates were calculated. The human development index (HDI) and current healthcare expenditure (CHE)-to-gross domestic product (GDP) ratio were included as indicators of socioeconomic status. Additionally, the numbers of new cases and deaths were predicted from 2025 to 2040 by multiplying the anticipated population during this period by age-standardized rates. In 2020, there were 166,925 new cases of brain and CNS cancers in Asia, indicating a 5-year prevalence rate of 9.40 per 100,000. We also estimated the total ASIR, ASMR, and MIR as 3.20, 2.60, and 0.83, respectively. There were significant negative correlations between HDI and MIR (correlation coefficient: − 0.538, p value < 0.001) and significant positive correlations between CHE/GDP% and ASIR (correlation coefficient: 0.388, p value: 0.010) and ASMR (correlation coefficient: 0.373, p value: 0.014). In 2040, there will be 232,000 new cases of brain and CNS cancers and 200,000 subsequent deaths in Asia. Our study revealed higher brain and CNS cancer rates in Western Asia among males and elderly individuals. These findings can aid policymakers in enhancing cancer care and suggest the consideration of risk factors in future research. © The Author(s) 2024.
Related Docs
View other Related Docs
1. Global Epidemiology and Socioeconomic Correlates of Salivary Gland Cancer From 2020 to 2040, Community Dentistry and Oral Epidemiology (2025)
2. Patterns of Better Breast Cancer Care in Countries With Higher Human Development Index and Healthcare Expenditure: Insights From Globocan 2020, Frontiers in Public Health (2023)
3. Assessing Performance of the Healthcare Access and Quality Index, Overall and by Select Age Groups, for 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019, The Lancet Global Health (2022)
4. Epidemiology of Brain and Other Central Nervous System Cancers in the North Africa and Middle East Region: A Systematic Analysis of the Global Burden of Disease Study 1990–2019, World Neurosurgery (2023)
5. The Global Incidence, Mortality, and Burden of Breast Cancer in 2019: Correlation With Smoking, Drinking, and Drug Use, Frontiers in Oncology (2022)
6. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 a Systematic Analysis for the Global Burden of Disease Study 2019, JAMA Oncology (2022)
7. Immune Checkpoint Inhibitor (Ici) Therapy in Central Nervous System Cancers: State-Of-The-Art and Future Outlook, International Immunopharmacology (2025)
8. Global, Regional, and National Burden and Quality of Care Index (Qci) of Thyroid Cancer: A Systematic Analysis of the Global Burden of Disease Study 1990–2017, Cancer Medicine (2021)
Experts (# of related papers)
View all Related Experts
Farshad Farzadfar (8)
Nima Rezaei (6)
Other Related Docs
9. Spatial Profiling Technologies and Applications for Brain Cancers, Expert Review of Molecular Diagnostics (2021)
10. Effect of Short-Term Fasting on the Cisplatin Activity in Human Oral Squamous Cell Carcinoma Cell Line Hn5 and Chemotherapy Side Effects, BMC Cancer (2024)
11. Human Development Inequality Index and Cancer Pattern: A Global Distributive Study, Asian Pacific Journal of Cancer Prevention (2016)
12. Burden of Breast Cancer and Attributable Risk Factors in the North Africa and Middle East Region, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019, Frontiers in Oncology (2023)
13. Measuring Performance on the Healthcare Access and Quality Index for 195 Countries and Territories and Selected Subnational Locations: A Systematic Analysis From the Global Burden of Disease Study 2016, The Lancet (2018)
14. Measuring Universal Health Coverage Based on an Index of Effective Coverage of Health Services in 204 Countries and Territories, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019, The Lancet (2020)
15. Trend of Incidence and Mortality of Brain and Central Nervous System Cancer in Iran From 1990 to 2017: A Global Burden of Disease-Based Study, Current Journal of Neurology (2022)
16. Burden of Thyroid Cancer in North Africa and Middle East 1990–2019, Frontiers in Oncology (2022)
17. Using a Social Marketing Approach to Increase the Pap-Smear Test Uptake: Randomized Controlled Trial Among Women Residing in Urban Region, BMC Women's Health (2025)
18. Global, Regional and National Burden of Bladder Cancer and Its Attributable Risk Factors in 204 Countries and Territories, 1990-2019: A Systematic Analysis for the Global Burden of Disease Study 2019, BMJ Global Health (2021)
19. Emerging Roles of Non-Coding Rnas in Modulating the Pi3k/Akt Pathway in Cancer, Non-coding RNA Research (2025)
20. Effects of Human Development Index and Its Components on Colorectal Cancer Incidence and Mortality: A Global Ecological Study, Asian Pacific Journal of Cancer Prevention (2016)
21. Incidence and Mortality of Colorectal Cancer and Relationships With the Human Development Index Across the World, Asian Pacific Journal of Cancer Prevention (2016)
22. National and Subnational Survey on Diabetes Burden and Quality of Care Index in Iran: A Systematic Analysis of the Global Burden of Disease Study 1990–2019, Journal of Diabetes and Metabolic Disorders (2022)
23. Examining the Completeness of Breast Cancer Pathology Reports Registered in the Population-Based Cancer Registration System and Spatial Analysis of the Incidence of This Cancer in Iran in 2016, International Journal of Cancer Management (2023)