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Morphine Modulates the Effects of Histamine H1 and H3 Receptors on Seizure Susceptibility in Pentylenetetrazole-Induced Seizure Model of Mice Publisher Pubmed



Aminikhoei H1, 2 ; Rahimibalaei M3 ; Amiri S1, 2 ; Hajmirzaian A1, 2 ; Hassanipour M1, 2 ; Shirzadian A1, 2 ; Gooshe M1, 2 ; Alijanpour S4 ; Mehr SE1, 2 ; Dehpour AR1, 2
Authors
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Authors Affiliations
  1. 1. Experimental Medicine Research Center, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
  4. 4. Department of Biology, Faculty of Sciences, Gonbad Kavous University, Gonbad, Iran

Source: European Journal of Pharmacology Published:2015


Abstract

Histamine regulates release of neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid (GABA), glutamate and also is involved in several functions in central nervous system (CNS). It has been shown that histamine participates in disorders like seizure. It has been well documented that morphine dose-dependently induces anti or proconvulsant effects. In the current study, we firstly showed that morphine (1 mg/kg) exerts anticonvulsant effects which significantly reversed by naltrexone administration. Secondly, we determined seizure threshold for H1 and H3 receptors agonists and antagonists in mouse model of pentylenetetrazole (PTZ)-induced clonic seizures. Our results showed that activation of H1 receptors by 2-(2-Pyridyl)-ethylamine exerts anticonvulsant properties while inhibition of H1 receptors by pyrilamine maleate induced proconvulsant effects. Furthermore, we showed that immepip dihydrobromide, a H3 receptor agonist, increased seizure susceptibility to PTZ whereas thioperamide, a H3 receptor antagonist increased seizure threshold. We also revealed that pretreatment with morphine potently reversed the effects of histaminergic system on seizure threshold suggesting the involvement of opioid system in alteration of seizure threshold by histaminergic drugs. © 2015 Elsevier B.V.
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