A Theoretical Strategy for Acceleration of Human Immune Response Against Sars-Cov-2: A Fusion Protein Harboring Virus-Binding and Pre-Exposed Antigen Domains Publisher



Rahmani R¹ ; Eivazi N¹ ; Paknejad M¹ ; Aminian M^{1, 2} Show Affiliations
Source: VirusDisease Published:2021

Abstract

Coronavirus disease 2019 (COVID-19) is a respiratory disease that outbreaks since December 2019 and spread globally. Various methods have been used to treat SARS-CoV-2 that is generally based on the information obtained from the therapeutic approaches used for SARS-COV and MERS patients. In this article, we introduce a theoretical strategy in which a two-domain fusion protein presents the virus to the immune system. This fusion protein contains a viral-binding domain such as the ACE2 domain and a domain such as the hepatitis B antigen that has previously been exposed to the immune system. This two-domain fusion protein, could be called “virus-presenting fusion protein”, would attach to the virus spike protein via the ACE2 domain while the hepatitis B antigen would be bound by anti-hepatitis B antibodies facilitating the opsonization and presentation of the virus to the immune system. We believe that this virus-presenting fusion protein will accelerate the immune response to the SARS-CoV-2 virus. © 2021, Indian Virological Society.