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Overview of the Current Promising Approaches for the Development of an Effective Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Vaccine Publisher Pubmed



Mirzaei R1, 2 ; Mohammadzadeh R3 ; Mahdavi F4 ; Badrzadeh F5 ; Kazemi S6 ; Ebrahimi M7 ; Soltani F8 ; Kazemi S6 ; Jeda AS9 ; Darvishmotevalli M10 ; Yousefimashouf R1 ; Keyvani H9 ; Karampoor S9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Parasitology and Mycology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  5. 5. Faculty of Medicine, Golestan University of Medical Sciences, Golestan, Iran
  6. 6. Students’ Seientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Environmental Health, School of Health, Guilan University of Medical Sciences, Rasht, Iran
  8. 8. Health Safety and Environment Management Department, Azad University, Ahvaz Branch, Ahvaz, Iran
  9. 9. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Research Center For Health, Safety And Environment (RCHSE), Alborz University of Medical Sciences, Karaj, Iran

Source: International Immunopharmacology Published:2020


Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Nevertheless, currently, no proven effective therapies for this virus exists. The vaccines are deemed as a significant part of disease prevention for emerging viral diseases, since, in several cases, other therapeutic choices are limited or non‐existent, or that diseases result in such an accelerated clinical worsening that the efficacy of treatments is restricted. Therefore, effective vaccines against COVID-19 are urgently required to overcome the tremendous burden of mortality and morbidity correlated with SARS-CoV-2. In this review, we will describe the latest evidence regarding outstanding vaccine approaches and the challenges for vaccine production. © 2020 Elsevier B.V.
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