Quercetin May Reduce the Risk of Developing the Symptoms of Covid-19 Publisher



Ajami M¹ ; Sotoudeheian M² ; Houshiarrad A³ ; Esmaili M³ ; Naeini F⁴ ; Nasrabadi FM¹ ; Doaei S⁵ ; Milanibonab A¹
Source: Avicenna Journal of Phytomedicine Published:2024

Abstract

Objective: Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-2 main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-19 were assessed in this article. Materials and Methods: Related papers on the inhibitory effects of quercetin against COVID-19 were collected using the following search strategy: “corona or coronavirus or COVID or COVID-19 or viral or virus” AND “nutrient or flavonoid or Quercetin”. Results: The findings indicated that quercetin can be considered an effective agent against COVID-19 because of its SARS-CoV-2 main protease and RNA-dependent RNA polymerase inhibitory effects. In addition, quercetin may attenuate angiotensin-converting enzyme-2 (ACE-2) receptors leading to a reduction of SARS-CoV-2 ability to enter host cells. Moreover, the antiviral, anti-inflammatory, and immunomodulatory activities of quercetin have been frequently reported. Conclusion: Quercetin may be an effective agent for managing the complications of COVID-19. Further longitudinal human studies are warranted. © 2024 Mashhad University of Medical Sciences. All rights reserved.