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The Association Analysis of Vascular Endothelial Growth Factor-2549 Insertion/ Deletion Variant and Endometriosis Risk Publisher



Sarhangi N1, 2 ; Mohseni S3 ; Aminimoghaddam S4 ; Rashidi BH5 ; Haghollahi F4 ; Qorbani M6 ; Amoli MM2 ; Shahrabifarahani M2
Authors
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Authors Affiliations
  1. 1. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: International Journal of Molecular and Cellular Medicine Published:2019


Abstract

Endometriosis is a debilitating disorder, defined as the presence of endometrial gland and stroma outside of the uterus. It may affect angiogenesis and vascular endothelial growth factor (VEGF) is one of the angiogenic factors that plays an important role in both physiological and pathological angiogenesis. The present study aimed to evaluate the association of VEGF-2549 insertion/deletion (I/D) polymorphism with endometriosis. This casecontrol study enrolled 244 (100 cases and 144 controls) women who were admitted for laparoscopy or laparotomy for gynecological procedures. Genomic DNA was separated from peripheral blood leukocytes and polymerase chain reaction (PCR) amplification was performed for genotyping of the VEGF gene Insertion/Deletion (I/D) polymorphism. The frequency of the II, ID, and DD genotype was 14%, 52% and 34% in patients versus 18.8%, 47.8% and 34% in controls. The results did not provide any evidence supporting the endometriosis risk related to the VEGF polymorphism in a group of Iranian women population. © 2020 Babol University of Medical Sciences.
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