Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells

Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells Publisher Pubmed

Naserzadeh P¹ ; Ansari Esfeh F¹ ; Kaviani M¹ ; Ashtari K⁴ ; Kheirbakhsh R² ; Salimi A³ ; Pourahmad J¹

Show Affiliations

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Science, Ardabil, Iran
4. Department of Medical Nanotechnology, Faculty of Advanced Technology in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Cutaneous and Ocular Toxicology Published:2018

Abstract

Purpose: Nanomaterials (NM) exhibit novel anticancer properties. Materials and methods: The toxicity of three nanoparticles that are currently being produced in high tonnage including single-walled carbon nanotube (SWCNT), multi-walled carbon nanotube (MWCNT) and Fe2O3 nanoparticles, were compared with normal and melanoma cells. Results: All tested nanoparticles induced selective toxicity and caspase 3 activation through mitochondria pathway in melanoma cells and mitochondria cause the generating of reactive oxygen species (ROS), mitochondrial membrane potential decline (MMP collapse), mitochondria swelling, and cytochrome c release. The pretreatment of butylated hydroxytoluene (BHT), a cell-permeable antioxidant and cyclosporine A (Cs. A), a mitochondrial permeability transition (MPT), pore sealing agent decreased cytotoxicity, caspase 3 activation, ROS generation, and mitochondrial damages induced by SWCNT, MWCNT, and IONPs. Conclusions: Our promising results provide a potential approach for the future therapeutic use of SWCNT, MWCNT, and IONPs in melanoma through mitochondrial targeting. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Related Docs

1. Nanoparticles As New Tools for Inhibition of Cancer Angiogenesis, Journal of Cellular Physiology (2018)

2. Targeting Ferroptosis As a Cell Death Pathway in Melanoma: From Molecular Mechanisms to Skin Cancer Treatment, International Immunopharmacology (2023)

3. Silk Fibroin Nanoparticle As a Novel Drug Delivery System, Journal of Controlled Release (2015)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (1)

Fatemeh Atyabi (1)

Style	Citing Format
MLA	Naserzadeh P, et al.. "Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells." Cutaneous and Ocular Toxicology, vol. 37, no. 2, 2018, pp. 157-166.
APA	Naserzadeh P, Ansari Esfeh F, Kaviani M, Ashtari K, Kheirbakhsh R, Salimi A, Pourahmad J (2018). Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells. Cutaneous and Ocular Toxicology, 37(2), 157-166.
Chicago	Naserzadeh P, Ansari Esfeh F, Kaviani M, Ashtari K, Kheirbakhsh R, Salimi A, Pourahmad J. "Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells." Cutaneous and Ocular Toxicology 37, no. 2 (2018): 157-166.
Harvard	Naserzadeh P et al. (2018) 'Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells', Cutaneous and Ocular Toxicology, 37(2), pp. 157-166.
Vancouver	Naserzadeh P, Ansari Esfeh F, Kaviani M, Ashtari K, Kheirbakhsh R, Salimi A, et al.. Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells. Cutaneous and Ocular Toxicology. 2018;37(2):157-166.
BibTex	@article{ author = {Naserzadeh P and Ansari Esfeh F and Kaviani M and Ashtari K and Kheirbakhsh R and Salimi A and Pourahmad J}, title = {Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells}, journal = {Cutaneous and Ocular Toxicology}, volume = {37}, number = {2}, pages = {157-166}, year = {2018} }
RIS	TY - JOUR AU - Naserzadeh P AU - Ansari Esfeh F AU - Kaviani M AU - Ashtari K AU - Kheirbakhsh R AU - Salimi A AU - Pourahmad J TI - Single-Walled Carbon Nanotube, Multi-Walled Carbon Nanotube and Fe2o3 Nanoparticles Induced Mitochondria Mediated Apoptosis in Melanoma Cells JO - Cutaneous and Ocular Toxicology VL - 37 IS - 2 SP - 157 EP - 166 PY - 2018 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract