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Intracellular Ros Induction by Ag@Zno Core-Shell Nanoparticles: Frontiers of Permanent Optically Active Holes in Breast Cancer Theranostic Publisher Pubmed



Ghaemi B1 ; Shaabani E1 ; Najafitaher R1 ; Jafari Nodooshan S2 ; Sadeghpour A4 ; Kharrazi S1 ; Amani A1, 3
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  2. 2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  3. 3. Medical Biomaterials Research Center (MBRC), Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  4. 4. Centre for X-Ray Analytics, Department of Material Meet Life, Swiss Federal Laboratories for Material Science and Technology (Empa), St. Gallen, 9014, Switzerland

Source: ACS Applied Materials and Interfaces Published:2018


Abstract

In this study, we investigated whether ZnO coating on Ag nanoparticles (NPs) tunes electron flux and hole figuration at the metal-semiconductor interface under UV radiation. This effect triggers the photoactivity and generation of reactive oxygen species from Ag@ZnO NPs, which results in enhanced cytotoxic effects and apoptotic cell death in human breast cancer cells (MDA-MB231). In this context, upregulation of apoptotic cascade proteins (i.e., Bax/Bcl2 association, p53, cytochrome c, and caspase-3) along with activation of oxidative stress proteins suggested the occurrence of apoptosis by Ag@ZnO NPs in cancer cells through the mitochondrial pathway. Also, preincubation of breast cancer cells with Ag@ZnO NPs in dark conditions muted NP-related toxic effects and consequent apoptotic fate, highlighting biocompatible properties of unexcited Ag@ZnO NPs. Furthermore, the diagnostic efficacy of Ag@ZnO NPs as computed tomography (CT)/optical nanoprobes was investigated. Results confirmed the efficacy of the photoactivated system in obtaining desirable outcomes from CT/optical imaging, which represents novel theranostic NPs for simultaneous imaging and treatment of cancer. © 2018 American Chemical Society.
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