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Covidctnet: An Open-Source Deep Learning Approach to Diagnose Covid-19 Using Small Cohort of Ct Images Publisher



Javaheri T1 ; Homayounfar M2 ; Amoozgar Z3 ; Reiazi R4, 5, 6 ; Homayounieh F7 ; Abbas E8 ; Laali A9 ; Radmard AR10 ; Gharib MH11 ; Mousavi SAJ12 ; Ghaemi O10 ; Babaei R13 ; Mobin HK13 ; Hosseinzadeh M14, 15 Show All Authors
Authors
  1. Javaheri T1
  2. Homayounfar M2
  3. Amoozgar Z3
  4. Reiazi R4, 5, 6
  5. Homayounieh F7
  6. Abbas E8
  7. Laali A9
  8. Radmard AR10
  9. Gharib MH11
  10. Mousavi SAJ12
  11. Ghaemi O10
  12. Babaei R13
  13. Mobin HK13
  14. Hosseinzadeh M14, 15
  15. Jahanbanesfahlan R16
  16. Seidi K16
  17. Kalra MK7
  18. Zhang G1, 17
  19. Chitkushev LT1, 17
  20. Haibekains B4, 5, 18, 19, 20
  21. Malekzadeh R21
  22. Rawassizadeh R1, 17
Show Affiliations
Authors Affiliations
  1. 1. Health Informatics Lab, Metropolitan College, Boston University, Boston, United States
  2. 2. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  3. 3. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, United States
  4. 4. Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada
  5. 5. Department of Medical Biophysics, University of Toronto, Toronto, Canada
  6. 6. Department of Medical Physics, School of Medicine, Iran university of Medical Sciences, Tehran, Iran
  7. 7. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, United States
  8. 8. Joint Department of Medical Imaging, University of Toronto, Toronto, Canada
  9. 9. Department of Infectious Diseases, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Radiology and Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  12. 12. Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran
  13. 13. Department of Radiology, Iran University of Medical Sciences, Tehran, Iran
  14. 14. Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam
  15. 15. Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran
  16. 16. Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  17. 17. Department of Computer Science, Metropolitan College, Boston University, Boston, United States
  18. 18. Department of Computer Science, University of Toronto, Toronto, ON, Canada
  19. 19. Ontario Institute for Cancer Research, Toronto, ON, Canada
  20. 20. Vector Institute for Artificial Intelligence, Toronto, ON, Canada
  21. 21. Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: npj Digital Medicine Published:2021


Abstract

Coronavirus disease 2019 (Covid-19) is highly contagious with limited treatment options. Early and accurate diagnosis of Covid-19 is crucial in reducing the spread of the disease and its accompanied mortality. Currently, detection by reverse transcriptase-polymerase chain reaction (RT-PCR) is the gold standard of outpatient and inpatient detection of Covid-19. RT-PCR is a rapid method; however, its accuracy in detection is only ~70–75%. Another approved strategy is computed tomography (CT) imaging. CT imaging has a much higher sensitivity of ~80–98%, but similar accuracy of 70%. To enhance the accuracy of CT imaging detection, we developed an open-source framework, CovidCTNet, composed of a set of deep learning algorithms that accurately differentiates Covid-19 from community-acquired pneumonia (CAP) and other lung diseases. CovidCTNet increases the accuracy of CT imaging detection to 95% compared to radiologists (70%). CovidCTNet is designed to work with heterogeneous and small sample sizes independent of the CT imaging hardware. To facilitate the detection of Covid-19 globally and assist radiologists and physicians in the screening process, we are releasing all algorithms and model parameter details as open-source. Open-source sharing of CovidCTNet enables developers to rapidly improve and optimize services while preserving user privacy and data ownership. © 2021, The Author(s).
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