Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage

Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage Publisher Pubmed

Mowla A¹ ; Shakibajahromi B² ; Shahjouei S³ ; Baharvahdat H⁴ ; Harandi AA⁵ ; Rahmani F⁶ ; Mondello S⁷ ; Rahimian N⁸ ; Cernigliaro A⁹ ; Hokmabadi ES¹⁰ ; Ebrahimzadeh SA¹¹ ; Ramezani M¹² ; Mehrvar K¹³ ; Farhoudi M¹⁰ Show All Authors

Mowla A¹
Shakibajahromi B²
Shahjouei S³
Baharvahdat H⁴
Harandi AA⁵
Rahmani F⁶
Mondello S⁷
Rahimian N⁸
Cernigliaro A⁹
Hokmabadi ES¹⁰
Ebrahimzadeh SA¹¹
Ramezani M¹²
Mehrvar K¹³
Farhoudi M¹⁰
Naderi S¹⁴
Fenderi SM⁴
Pishjoo M⁴
Alizada O¹⁵
Purroy F¹⁶
Requena M¹⁷
Tsivgoulis G¹⁸
Zand R³

Show Affiliations

1. Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, California, United States
2. Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3. Neurology Department, Neuroscience Institute, Geisinger Health System, PA, United States
4. Division of Neuroendovascular Surgery, Department of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
5. Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Department of Emergency Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
7. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
8. Department of Neurology, Tufts Medical Center, Boston, MA, United States
9. Regional Health Authority of Sicily, Palermo, Italy
10. Neurosciences Resarch Center, Tabriz University of Medical Sciences, Tabriz, Iran
11. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
12. Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
13. Department of Neurology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
14. Neurosurgery Department, Tehran University of Medical Sciences, Tehran, Iran
15. Department of Neurosurgery, Baskent University, Faculty of Medicine, Istanbul, Turkey
16. Department of Neurology, Hospital Arnau de Vilanova, Institut de Recerca Biomedica de Lleida (IRBLLeida), Universitat de Lleida UdL Lleida, Spain
17. Stroke Unit, Department of Neurology, Hospital Vall d'Hebron, Department de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain
18. Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, â€œAttikonâ€� University Hospital, Athens, Greece

Source: Journal of the Neurological Sciences Published:2023

Abstract

Background: SARS-CoV-2 infection may be associated with uncommon complications such as intracerebral hemorrhage (ICH), with a high mortality rate. We compared a series of hospitalized ICH cases infected with SARS-CoV-2 with a non-SARS-CoV-2 infected control group and evaluated if the SARS-CoV-2 infection is a predictor of mortality in ICH patients. Methods: In a multinational retrospective study, 63 cases of ICH in SARS-CoV-2 infected patients admitted to 13 tertiary centers from the beginning of the pandemic were collected. We compared the clinical and radiological characteristics and in-hospital mortality of these patients with a control group of non-SARS-CoV-2 infected ICH patients of a previous cohort from the country where the majority of cases were recruited. Results: Among 63 ICH patients with SARS-CoV-2 infection, 23 (36.5%) were women. Compared to the non-SARS-CoV-2 infected control group, in SARS-CoV-2 infected patients, ICH occurred at a younger age (61.4 ± 18.1 years versus 66.8 ± 16.2 years, P = 0.044). These patients had higher median ICH scores ([3 (IQR 2–4)] versus [2 (IQR 1–3)], P = 0.025), a more frequent history of diabetes (34% versus 16%, P = 0.007), and lower platelet counts (177.8 ± 77.8 × 109/L versus 240.5 ± 79.3 × 109/L, P < 0.001). The in-hospital mortality was not significantly different between cases and controls (65% versus 62%, P = 0.658) in univariate analysis; however, SARS-CoV-2 infection was significantly associated with in-hospital mortality (aOR = 4.3, 95% CI: 1.28–14.52) in multivariable analysis adjusting for potential confounders. Conclusion: Infection with SARS-CoV-2 may be associated with increased odds of in-hospital mortality in ICH patients. © 2022

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Style	Citing Format
MLA	Mowla A, et al.. "Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage." Journal of the Neurological Sciences, vol. 444, no. , 2023, pp. -.
APA	Mowla A, Shakibajahromi B, Shahjouei S, Baharvahdat H, Harandi AA, Rahmani F, Mondello S, Rahimian N, Cernigliaro A, Hokmabadi ES, Ebrahimzadeh SA, Ramezani M, Mehrvar K, Farhoudi M, Naderi S, Fenderi SM, Pishjoo M, Alizada O, Purroy F, ... Zand R (2023). Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage. Journal of the Neurological Sciences, 444(), -.
Chicago	Mowla A, Shakibajahromi B, Shahjouei S, Baharvahdat H, Harandi AA, Rahmani F, Mondello S, et al.. "Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage." Journal of the Neurological Sciences 444, no. (2023): -.
Harvard	Mowla A et al. (2023) 'Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage', Journal of the Neurological Sciences, 444(), pp. -.
Vancouver	Mowla A, Shakibajahromi B, Shahjouei S, Baharvahdat H, Harandi AA, Rahmani F, et al.. Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage. Journal of the Neurological Sciences. 2023;444():-.
BibTex	@article{ author = {Mowla A and Shakibajahromi B and Shahjouei S and Baharvahdat H and Harandi AA and Rahmani F and Mondello S and Rahimian N and Cernigliaro A and Hokmabadi ES and Ebrahimzadeh SA and Ramezani M and Mehrvar K and Farhoudi M and Naderi S and Fenderi SM and Pishjoo M and Alizada O and Purroy F and Requena M and Tsivgoulis G and Zand R}, title = {Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage}, journal = {Journal of the Neurological Sciences}, volume = {444}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Mowla A AU - Shakibajahromi B AU - Shahjouei S AU - Baharvahdat H AU - Harandi AA AU - Rahmani F AU - Mondello S AU - Rahimian N AU - Cernigliaro A AU - Hokmabadi ES AU - Ebrahimzadeh SA AU - Ramezani M AU - Mehrvar K AU - Farhoudi M AU - Naderi S AU - Fenderi SM AU - Pishjoo M AU - Alizada O AU - Purroy F AU - Requena M AU - Tsivgoulis G AU - Zand R TI - Sars-Cov-2 Infection Might Be a Predictor of Mortality in Intracerebral Hemorrhage JO - Journal of the Neurological Sciences VL - 444 IS - SP - EP - PY - 2023 ER -

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