Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study

Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study Publisher Pubmed

Shahjouei S¹ ; Naderi S^{1, 28} ; Li J² ; Khan A¹ ; Chaudhary D¹ ; Farahmand G^{3, 12} ; Male S⁴ ; Griessenauer C¹ ; Sabra M⁵ ; Mondello S⁶ ; Cernigliaro A⁷ ; Khodadadi F⁸ ; Dev A⁸ ; Goyal N⁹ Show All Authors

Shahjouei S¹
Naderi S^{1, 28}
Li J²
Khan A¹
Chaudhary D¹
Farahmand G^{3, 12}
Male S⁴
Griessenauer C¹
Sabra M⁵
Mondello S⁶
Cernigliaro A⁷
Khodadadi F⁸
Dev A⁸
Goyal N⁹
Ranjiburachaloo S^{3, 12}
Olulana O¹
Avula V¹
Ebrahimzadeh SA¹⁰
Alizada O¹¹
Hanci MM¹¹
Ghorbani A¹²
Vaghefi Far A¹³
Ranta A^{13, 14}
Punter M^{13, 14}
Ramezani M¹⁵
Ostadrahimi N²⁸
Tsivgoulis G^{9, 16}
Fragkou PC¹⁷
Nowrouzisohrabi P¹⁸
Karofylakis E¹⁷
Tsiodras S¹⁷
Neshin Aghayari Sheikh S¹⁹
Saberi A¹⁹
Niemela M²⁰
Rezai Jahromi B²⁰
Mowla A²¹
Mashayekhi M²²
Bavarsad Shahripour R⁹
Sajedi SA²³
Ghorbani M²⁴
Kia A²⁵
Rahimian N²⁶
Abedi V^{2, 27}
Zand R^{1, 9}

Show Affiliations

1. Neurology Department, Neuroscience Institute, Geisinger Health System, Danville, PA, United States
2. Department of Molecular and Functional Genomics, Geisinger Health System, Danville, PA, United States
3. Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Neurology Department, Vidant Medical Center, Greenville, NC, United States
5. Neurosciences Research Center (NRC), Lebanese University/ Medical School, Beirut, Lebanon
6. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
7. Regional Health Authority of Sicily, Palermo, Italy
8. PES University, Bengaluru, Karnataka, India
9. Neurology Department, University of Tennessee Health Science Center, Tennessee, United States
10. Radiology Department, Yasrebi Hospital, Kashan, Iran
11. Neurosurgery Department, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
12. Neurology Department, Tehran University of Medical Sciences, Tehran, Iran
13. Department of Neurology, Wellington Hospital, Wellington, New Zealand
14. Department of Medicine, University of Otago, Wellington, New Zealand
15. Neurology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
16. Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, â€œAttikonâ€� University Hospital, Athens, Greece
17. Fourth Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece
18. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
19. Neurology Department, Poursina Hospital, Guilan University of Medical Sciences, Guilan, Iran
20. Department of Neurosurgery, Helsinki University Hospital, Helsinki, Finland
21. Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, California, United States
22. Internal medicine Department, Tabriz University of medical sciences, Tabriz, Iran
23. Neuroscience Research Center, Department of Neurology, Golestan University of Medical Sciences, Gorgan, Iran
24. Divisions of Vascular and Endovascular Neurosurgery and Neurology, Firoozgar Hospital and Rasoul-Akram hospital, Iran University of Medical Sciences, Tehran, Iran
25. Icahn school of medicine at Mount Sinai, Department of Population Health Science and Policy, Institute for Healthcare Delivery Science, New York, United States
26. Neurology Department, Yasrebi Hospital, Kashan, Iran
27. Biocomplexity Institute, Virginia Tech, Blacksburg, VA, United States
28. Neurosurgery Department, Tehran University of Medical Sciences, Tehran, Iran

Source: EBioMedicine Published:2020

Abstract

Background: There is an increased attention to stroke following SARS-CoV-2. The goal of this study was to better depict the short-term risk of stroke and its associated factors among SARS-CoV-2 hospitalized patients. Methods: This multicentre, multinational observational study includes hospitalized SARS-CoV-2 patients from North and South America (United States, Canada, and Brazil), Europe (Greece, Italy, Finland, and Turkey), Asia (Lebanon, Iran, and India), and Oceania (New Zealand). The outcome was the risk of subsequent stroke. Centres were included by non-probability sampling. The counts and clinical characteristics including laboratory findings and imaging of the patients with and without a subsequent stroke were recorded according to a predefined protocol. Quality, risk of bias, and heterogeneity assessments were conducted according to ROBINS-E and Cochrane Q-test. The risk of subsequent stroke was estimated through meta-analyses with random effect models. Bivariate logistic regression was used to determine the parameters with predictive outcome value. The study was reported according to the STROBE, MOOSE, and EQUATOR guidelines. Findings: We received data from 26,175 hospitalized SARS-CoV-2 patients from 99 tertiary centres in 65 regions of 11 countries until May 1st, 2020. A total of 17,799 patients were included in meta-analyses. Among them, 156(0.9%) patients had a stroke—123(79%) ischaemic stroke, 27(17%) intracerebral/subarachnoid hemorrhage, and 6(4%) cerebral sinus thrombosis. Subsequent stroke risks calculated with meta-analyses, under low to moderate heterogeneity, were 0.5% among all centres in all countries, and 0.7% among countries with higher health expenditures. The need for mechanical ventilation (OR: 1.9, 95% CI:1.1–3.5, p = 0.03) and the presence of ischaemic heart disease (OR: 2.5, 95% CI:1.4–4.7, p = 0.006) were predictive of stroke. Interpretation: The results of this multi-national study on hospitalized patients with SARS-CoV-2 infection indicated an overall stroke risk of 0.5%(pooled risk: 0.9%). The need for mechanical ventilation and the history of ischaemic heart disease are the independent predictors of stroke among SARS-CoV-2 patients. Funding: None. © 2020 The Authors

Related Docs

View other Related Docs

1. Sars-Cov-2 and Stroke Characteristics: A Report From the Multinational Covid-19 Stroke Study Group, Stroke (2021)

2. Pathogenesis, Clinical Manifestations and Complications of Coronavirus Disease 2019 (Covid-19), Future Microbiology (2020)

3. Covid-19: Review of a 21St Century Pandemic From Etiology to Neuro-Psychiatric Implications, Journal of Alzheimer's Disease (2020)

4. Cardiovascular Diseases Burden in Covid-19: Systematic Review and Meta-Analysis, American Journal of Emergency Medicine (2021)

5. Sars-Cov-2 Is a Culprit for Some, But Not All Acute Ischemic Strokes: A Report From the Multinational Covid-19 Stroke Study Group, Journal of Clinical Medicine (2021)

6. Covid-19 Infection and Stroke Risk, Reviews in the Neurosciences (2021)

7. Sars-Cov-2 and Acute Cerebrovascular Events: An Overview, Journal of Clinical Medicine (2021)

8. Anosmia: A Missing Link in the Neuroimmunology of Coronavirus Disease 2019 (Covid-19), Reviews in the Neurosciences (2020)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (22)

Azita Hajhossein Talasaz (7)

Style	Citing Format
MLA	Shahjouei S, et al.. "Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study." EBioMedicine, vol. 59, no. , 2020, pp. -.
APA	Shahjouei S, Naderi S, Li J, Khan A, Chaudhary D, Farahmand G, Male S, Griessenauer C, Sabra M, Mondello S, Cernigliaro A, Khodadadi F, Dev A, Goyal N, Ranjiburachaloo S, Olulana O, Avula V, Ebrahimzadeh SA, Alizada O, ... Zand R (2020). Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study. EBioMedicine, 59(), -.
Chicago	Shahjouei S, Naderi S, Li J, Khan A, Chaudhary D, Farahmand G, Male S, et al.. "Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study." EBioMedicine 59, no. (2020): -.
Harvard	Shahjouei S et al. (2020) 'Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study', EBioMedicine, 59(), pp. -.
Vancouver	Shahjouei S, Naderi S, Li J, Khan A, Chaudhary D, Farahmand G, et al.. Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study. EBioMedicine. 2020;59():-.
BibTex	@article{ author = {Shahjouei S and Naderi S and Li J and Khan A and Chaudhary D and Farahmand G and Male S and Griessenauer C and Sabra M and Mondello S and Cernigliaro A and Khodadadi F and Dev A and Goyal N and Ranjiburachaloo S and Olulana O and Avula V and Ebrahimzadeh SA and Alizada O and Hanci MM and Ghorbani A and Vaghefi Far A and Ranta A and Punter M and Ramezani M and Ostadrahimi N and Tsivgoulis G and Fragkou PC and Nowrouzisohrabi P and Karofylakis E and Tsiodras S and Neshin Aghayari Sheikh S and Saberi A and Niemela M and Rezai Jahromi B and Mowla A and Mashayekhi M and Bavarsad Shahripour R and Sajedi SA and Ghorbani M and Kia A and Rahimian N and Abedi V and Zand R}, title = {Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study}, journal = {EBioMedicine}, volume = {59}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Shahjouei S AU - Naderi S AU - Li J AU - Khan A AU - Chaudhary D AU - Farahmand G AU - Male S AU - Griessenauer C AU - Sabra M AU - Mondello S AU - Cernigliaro A AU - Khodadadi F AU - Dev A AU - Goyal N AU - Ranjiburachaloo S AU - Olulana O AU - Avula V AU - Ebrahimzadeh SA AU - Alizada O AU - Hanci MM AU - Ghorbani A AU - Vaghefi Far A AU - Ranta A AU - Punter M AU - Ramezani M AU - Ostadrahimi N AU - Tsivgoulis G AU - Fragkou PC AU - Nowrouzisohrabi P AU - Karofylakis E AU - Tsiodras S AU - Neshin Aghayari Sheikh S AU - Saberi A AU - Niemela M AU - Rezai Jahromi B AU - Mowla A AU - Mashayekhi M AU - Bavarsad Shahripour R AU - Sajedi SA AU - Ghorbani M AU - Kia A AU - Rahimian N AU - Abedi V AU - Zand R TI - Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study JO - EBioMedicine VL - 59 IS - SP - EP - PY - 2020 ER -

Style

Citing Format

MLA

Shahjouei S, et al.. "Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study." EBioMedicine, vol. 59, no. , 2020, pp. -.

APA

Shahjouei S, Naderi S, Li J, Khan A, Chaudhary D, Farahmand G, Male S, Griessenauer C, Sabra M, Mondello S, Cernigliaro A, Khodadadi F, Dev A, Goyal N, Ranjiburachaloo S, Olulana O, Avula V, Ebrahimzadeh SA, Alizada O, ... Zand R (2020). Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study. EBioMedicine, 59(), -.

Chicago

Shahjouei S, Naderi S, Li J, Khan A, Chaudhary D, Farahmand G, Male S, et al.. "Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study." EBioMedicine 59, no. (2020): -.

Harvard

Shahjouei S et al. (2020) 'Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study', EBioMedicine, 59(), pp. -.

Vancouver

Shahjouei S, Naderi S, Li J, Khan A, Chaudhary D, Farahmand G, et al.. Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study. EBioMedicine. 2020;59():-.

BibTex

@article{ author = {Shahjouei S and Naderi S and Li J and Khan A and Chaudhary D and Farahmand G and Male S and Griessenauer C and Sabra M and Mondello S and Cernigliaro A and Khodadadi F and Dev A and Goyal N and Ranjiburachaloo S and Olulana O and Avula V and Ebrahimzadeh SA and Alizada O and Hanci MM and Ghorbani A and Vaghefi Far A and Ranta A and Punter M and Ramezani M and Ostadrahimi N and Tsivgoulis G and Fragkou PC and Nowrouzisohrabi P and Karofylakis E and Tsiodras S and Neshin Aghayari Sheikh S and Saberi A and Niemela M and Rezai Jahromi B and Mowla A and Mashayekhi M and Bavarsad Shahripour R and Sajedi SA and Ghorbani M and Kia A and Rahimian N and Abedi V and Zand R}, title = {Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study}, journal = {EBioMedicine}, volume = {59}, number = {}, pages = {-}, year = {2020} }

RIS

TY - JOUR
AU - Shahjouei S
AU - Naderi S
AU - Li J
AU - Khan A
AU - Chaudhary D
AU - Farahmand G
AU - Male S
AU - Griessenauer C
AU - Sabra M
AU - Mondello S
AU - Cernigliaro A
AU - Khodadadi F
AU - Dev A
AU - Goyal N
AU - Ranjiburachaloo S
AU - Olulana O
AU - Avula V
AU - Ebrahimzadeh SA
AU - Alizada O
AU - Hanci MM
AU - Ghorbani A
AU - Vaghefi Far A
AU - Ranta A
AU - Punter M
AU - Ramezani M
AU - Ostadrahimi N
AU - Tsivgoulis G
AU - Fragkou PC
AU - Nowrouzisohrabi P
AU - Karofylakis E
AU - Tsiodras S
AU - Neshin Aghayari Sheikh S
AU - Saberi A
AU - Niemela M
AU - Rezai Jahromi B
AU - Mowla A
AU - Mashayekhi M
AU - Bavarsad Shahripour R
AU - Sajedi SA
AU - Ghorbani M
AU - Kia A
AU - Rahimian N
AU - Abedi V
AU - Zand R
TI - Risk of Stroke in Hospitalized Sars-Cov-2 Infected Patients: A Multinational Study
JO - EBioMedicine
VL - 59
IS -
SP -
EP -
PY - 2020
ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract