Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series

Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series Publisher Pubmed

Mowla A¹ ; Shakibajahromi B² ; Shahjouei S³ ; Borhanihaghighi A² ; Rahimian N⁴ ; Baharvahdat H⁵ ; Naderi S⁶ ; Khorvash F⁷ ; Altafi D⁸ ; Ebrahimzadeh SA⁹ ; Farahmand G¹⁰ ; Vaghefi Far A¹⁰ ; Sharma VK¹¹ ; Neshin SAS¹² Show All Authors

Mowla A¹
Shakibajahromi B²
Shahjouei S³
Borhanihaghighi A²
Rahimian N⁴
Baharvahdat H⁵
Naderi S⁶
Khorvash F⁷
Altafi D⁸
Ebrahimzadeh SA⁹
Farahmand G¹⁰
Vaghefi Far A¹⁰
Sharma VK¹¹
Neshin SAS¹²
Tsivgoulis G^{13, 14}
Zand R^{3, 14}

Show Affiliations

1. Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, California, United States
2. Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3. Neurology Department, Neuroscience Institute, Geisinger Health System, PA, United States
4. Neurology Department, Yasrebi Hospital, Kashan, Iran
5. Division of Neuroendovascular Surgery, Department of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
6. Neurosurgery Department, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
8. Department of Neurology, Alavi Hospital, Ardabil University of Medical Sciences, Ardabil, Iran
9. Department of Radiology, Yasrebi Hospital, Kashan, Iran
10. Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
11. Division of Neurology, National University Health System, School of Medicine, National University of Singapore, Singapore
12. Neuroscience Research Center, Guilan University of Medical Sciences, Guilan, Iran
13. Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, â€œAttikonâ€� University Hospital, Athens, Greece
14. Neurology Department, University of Tennessee Health Science Center, TN, United States

Source: Journal of the Neurological Sciences Published:2020

Abstract

Background: SARS-CoV-2 induced coagulopathy can lead to thrombotic complications such as stroke. Cerebral venous sinus thrombosis (CVST) is a less common type of stroke which might be triggered by COVID-19. We present a series of CVST cases with SARS-CoV-2 infection. Methods: In a multinational retrospective study, we collected all cases of CVST in SARS-CoV-2 infected patients admitted to nine tertiary stroke centers from the beginning of the pandemic to June 30th, 2020. We compared the demographics, clinical and radiological characteristics, risk factors, and outcome of these patients with a control group of non-SARS-CoV-2 infected CVST patients in the same seasonal period of the years 2012–2016 from the country where the majority of cases were recruited. Results: A total of 13 patients fulfilled the inclusion criteria (62% women, mean age 50.9 ± 11.2 years). Six patients were discharged with good outcomes (mRS ≤ 2) and three patients died in hospital. Compared to the control group, the SARS-CoV-2 infected patients were significantly older (50.9 versus 36.7 years, p < 0.001), had a lower rate of identified CVST risk factors (23.1% versus 84.2%, p < 0.001), had more frequent cortical vein involvement (38.5% versus 10.5%, p: 0.025), and a non-significant higher rate of in-hospital mortality (23.1% versus 5.3%, p: 0.073). Conclusion: CVST should be considered as potential comorbidity in SARS-CoV-2 infected patients presenting with neurological symptoms. Our data suggest that compared to non-SARS-CoV-2 infected patients, CVST occurs in older patients, with lower rates of known CVST risk factors and might lead to a poorer outcome in the SARS-CoV-2 infected group. © 2020

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Style	Citing Format
MLA	Mowla A, et al.. "Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series." Journal of the Neurological Sciences, vol. 419, no. , 2020, pp. -.
APA	Mowla A, Shakibajahromi B, Shahjouei S, Borhanihaghighi A, Rahimian N, Baharvahdat H, Naderi S, Khorvash F, Altafi D, Ebrahimzadeh SA, Farahmand G, Vaghefi Far A, Sharma VK, Neshin SAS, Tsivgoulis G, Zand R (2020). Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series. Journal of the Neurological Sciences, 419(), -.
Chicago	Mowla A, Shakibajahromi B, Shahjouei S, Borhanihaghighi A, Rahimian N, Baharvahdat H, Naderi S, et al.. "Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series." Journal of the Neurological Sciences 419, no. (2020): -.
Harvard	Mowla A et al. (2020) 'Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series', Journal of the Neurological Sciences, 419(), pp. -.
Vancouver	Mowla A, Shakibajahromi B, Shahjouei S, Borhanihaghighi A, Rahimian N, Baharvahdat H, et al.. Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series. Journal of the Neurological Sciences. 2020;419():-.
BibTex	@article{ author = {Mowla A and Shakibajahromi B and Shahjouei S and Borhanihaghighi A and Rahimian N and Baharvahdat H and Naderi S and Khorvash F and Altafi D and Ebrahimzadeh SA and Farahmand G and Vaghefi Far A and Sharma VK and Neshin SAS and Tsivgoulis G and Zand R}, title = {Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series}, journal = {Journal of the Neurological Sciences}, volume = {419}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Mowla A AU - Shakibajahromi B AU - Shahjouei S AU - Borhanihaghighi A AU - Rahimian N AU - Baharvahdat H AU - Naderi S AU - Khorvash F AU - Altafi D AU - Ebrahimzadeh SA AU - Farahmand G AU - Vaghefi Far A AU - Sharma VK AU - Neshin SAS AU - Tsivgoulis G AU - Zand R TI - Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series JO - Journal of the Neurological Sciences VL - 419 IS - SP - EP - PY - 2020 ER -

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