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Association Between Abo Blood Group and Severity of Coronary Artery Disease in Unstable Angina



Omidi N1 ; Khorgami MR2 ; Effatpanah M3 ; Khatami F4 ; Mashhadizadeh M5 ; Jalali A6 ; Hekmat H7
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Authors Affiliations
  1. 1. Cardiac Primary Prevention Research Center, Tehran Heart Center, Department of Cardiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Rajaie Heart Center, Department of Pediatric Cardiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Psychiatry, School of Medicine, Ziaeian Hospital, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Cardiology, School of Medicine International Campus, Tehran University of Medical Sciences, Iran
  6. 6. Tehran Heart Center, Department of Research, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Cardiology, School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: ARYA Atherosclerosis Published:2017

Abstract

BACKGROUND: ABO blood groups are genetically transmitted through chromosome 9 at locus 9q34. It is supposed that there is a locus on 9p21, which has a role in developing coronary artery disease. METHODS: Our study population consisted of 309 patients with unstable angina admitted to the Ziaeian Hospital, Tehran, Iran, who underwent coronary angiography. The association between types of blood group (O and non-O) with the severity of coronary artery disease was investigated. RESULTS: Compared to the non-O groups, the O group had more severe coronary artery involvement (P = 0.004). CONCLUSION: Our study supports recent suggestions on the association between blood group and coronary artery disease. Further studies are needed to evaluate the effect of blood group on atherosclerosis. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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