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State of the Neoadjuvant Therapy for Glioblastoma Multiforme—Where Do We Stand? Publisher



Nabian N1, 2 ; Ghalehtaki R1, 2 ; Zeinalizadeh M3 ; Balana C4 ; Jablonska PA5
Authors
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Authors Affiliations
  1. 1. Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. B.ARGO (Badalona Applied Research Group of Oncology), Medical Oncology Department, Catalan Institute of Oncology Badalona, Badalona, Spain
  5. 5. Radiation Oncology Department, Clinica Universidad de Navarra, Pamplona, Spain

Source: Neuro-Oncology Advances Published:2024


Abstract

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. Despite several investigations in this field, maximal safe resection followed by chemoradiotherapy and adjuvant temozolomide with or without tumor-treating fields remains the standard of care with poor survival outcomes. Many endeavors have failed to make a dramatic change in the outcomes of GBM patients.This study aimed to review the available strategies for newly diagnosed GBM in the neoadjuvant setting, which have been mainly neglected in contrast to other solid tumors. © The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.