Therapeutic Potentials of Curcumin in the Treatment of Glioblstoma Publisher Pubmed



Shabaninejad Z^{1, 2} ; Pourhanifeh MH³ ; Movahedpour A^{4, 5} ; Mottaghi R⁶ ; Nickdasti A⁷ ; Mortezapour E⁷ ; Shafiee A⁸ ; Hajighadimi S⁸ ; Moradizarmehri S⁸ ; Sadeghian M⁹ ; Mousavi SM¹⁰ ; Mirzaei H⁷
Source: European Journal of Medicinal Chemistry Published:2020

Abstract

Glioblastoma multiforme (GBM), a greatly aggressive malignancy of the brain, is correlated with a poor prognosis and low rate of survival. Up to now, chemotherapy and radiation therapy after surgical approaches have been the treatments increasing the survival rates. The low efficacy of mentioned therapies as well as their side-effects has forced researchers to explore an appropriate alternative or complementary treatment for glioblastoma. In experimental models, it has been shown that curcumin has therapeutic potentials to fight against GBM. Given that curcumin has pharmacological effects against cancer stem cells, as major causes of resistance to therapy in glioblastoma cells. Moreover, it has been showed that curcumin exerts its therapeutic effects on GBM cells via affecting on apoptosis, oxidant system, and inflammatory pathways. Curcumin would possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as therapeutic agent in the treatment of GBM. © 2020 Elsevier Masson SAS