Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders

Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders Publisher Pubmed

Pakzad R^{1, 2} ; Nedjat S³ ; Salehiniya H⁴ ; Mansournia N⁵ ; Etminan M⁶ ; Nazemipour M³ ; Pakzad I⁷ ; Mansournia MA³

Show Affiliations

1. Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran
2. Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, PO Box: 14155-6446, Tehran, Iran
4. Department of Epidemiology and Biostatistics, School of Health, Birjand University of Medical Sciences, South Khorasan, Iran
5. Department of Endocrinology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
6. Departments of Ophthalmology and Visual Sciences, Medicine and Pharmacology, University of British Columbia, Vancouver, Canada
7. Department of Microbiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Source: BMC Medical Research Methodology Published:2023

Abstract

Purpose: This study was conducted to evaluate the effect of alcohol consumption on breast cancer, adjusting for alcohol consumption misclassification bias and confounders. Methods: This was a case-control study of 932 women with breast cancer and 1000 healthy control. Using probabilistic bias analysis method, the association between alcohol consumption and breast cancer was adjusted for the misclassification bias of alcohol consumption as well as a minimally sufficient set of adjustment of confounders derived from a causal directed acyclic graph. Population attributable fraction was estimated using the Miettinen’s Formula. Results: Based on the conventional logistic regression model, the odds ratio estimate between alcohol consumption and breast cancer was 1.05 (95% CI: 0.57, 1.91). However, the adjusted estimates of odds ratio based on the probabilistic bias analysis ranged from 1.82 to 2.29 for non-differential and from 1.93 to 5.67 for differential misclassification. Population attributable fraction ranged from 1.51 to 2.57% using non-differential bias analysis and 1.54–3.56% based on differential bias analysis. Conclusion: A marked measurement error was in self-reported alcohol consumption so after correcting misclassification bias, no evidence against independence between alcohol consumption and breast cancer changed to a substantial positive association. © 2023, The Author(s).

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Mohammad Ali Mansournia (73)

Saharnaz Nedjat (10)

Style	Citing Format
MLA	Pakzad R, et al.. "Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders." BMC Medical Research Methodology, vol. 23, no. 1, 2023, pp. -.
APA	Pakzad R, Nedjat S, Salehiniya H, Mansournia N, Etminan M, Nazemipour M, Pakzad I, Mansournia MA (2023). Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders. BMC Medical Research Methodology, 23(1), -.
Chicago	Pakzad R, Nedjat S, Salehiniya H, Mansournia N, Etminan M, Nazemipour M, Pakzad I, Mansournia MA. "Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders." BMC Medical Research Methodology 23, no. 1 (2023): -.
Harvard	Pakzad R et al. (2023) 'Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders', BMC Medical Research Methodology, 23(1), pp. -.
Vancouver	Pakzad R, Nedjat S, Salehiniya H, Mansournia N, Etminan M, Nazemipour M, et al.. Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders. BMC Medical Research Methodology. 2023;23(1):-.
BibTex	@article{ author = {Pakzad R and Nedjat S and Salehiniya H and Mansournia N and Etminan M and Nazemipour M and Pakzad I and Mansournia MA}, title = {Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders}, journal = {BMC Medical Research Methodology}, volume = {23}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Pakzad R AU - Nedjat S AU - Salehiniya H AU - Mansournia N AU - Etminan M AU - Nazemipour M AU - Pakzad I AU - Mansournia MA TI - Effect of Alcohol Consumption on Breast Cancer: Probabilistic Bias Analysis for Adjustment of Exposure Misclassification Bias and Confounders JO - BMC Medical Research Methodology VL - 23 IS - 1 SP - EP - PY - 2023 ER -

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