Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo

Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo Publisher Pubmed

Mahdikia H^{1, 2} ; Saadati F² ; Alizadeh AM³ ; Khalighfard S⁴ ; Bekeschus S² ; Shokri B¹

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1. Laser and Plasma Research Institute, Shahid Beheshti University, Tehran, Iran
2. Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany
3. Breast Diseases Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Research Center on Developing Advanced Technologies, Tehran, Iran

Source: Scientific Reports Published:2023

Abstract

A multiferroic nanostructure of manganese ferrite barium-titanate called magneto-electric nanoparticles (MENs) was synthesized by a co-precipitation method. FTIR, Raman spectroscopy, TEM, and X-ray diffraction confirmed the presence of spinel core and perovskite shell phases with average crystallite sizes of 70–90 nm. Magnetic, optical, and magnetoelectrical properties of MENs were investigated using VSM, UV-Vis spectrophotometry, DLS, and EIS spectroscopy techniques. After pre-activation by low-pressure argon (Ar) plasma, the MENs were functionalized by a highly hydrophilic acrylic acid and Oxygen (AAc+O2) mixture to produce COOH and C=O-rich surfaces. The loading and release of doxorubicin hydrochloride (DOX) on MENs were investigated using UV-vis and fluorescence spectrophotometry under alternating low-frequency magnetic fields. Plasma treatment enabled drug-loading control by changing the particles’ roughness as physical adsorption and creating functional groups for chemical absorption. This led to reduced metabolic activity and cell adherences associated with elevated expression of pro-apoptotic genes (BCL-2, caspase 3) in 4T1 breast cancer cells in vitro exposed to alternating current magnetic field (ACMF) compared to MENs-DOX without field exposure. ACMF-potentiated anticancer effects of MENs were validated in vivo in tumor-bearing Balb/C mice. Altogether, our results suggest potentiated drug loading of MENs showing superior anticancer activity in vitro and in vivo when combined with ACMF. © 2023, Springer Nature Limited.

2. Synthesis and Characterization of a Novel, Ph-Responsive Sustained Release Nanocarrier Using Polyethylene Glycol, Graphene Oxide, and Natural Silk Fibroin Protein by a Green Nano Emulsification Method to Enhance Cancer Treatment, International Journal of Biological Macromolecules (2023)

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Alimohammad Alizadeh (1)

Mona Navaei-Nigjeh (1)

Style	Citing Format
MLA	Mahdikia H, et al.. "Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo." Scientific Reports, vol. 13, no. 1, 2023, pp. -.
APA	Mahdikia H, Saadati F, Alizadeh AM, Khalighfard S, Bekeschus S, Shokri B (2023). Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo. Scientific Reports, 13(1), -.
Chicago	Mahdikia H, Saadati F, Alizadeh AM, Khalighfard S, Bekeschus S, Shokri B. "Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo." Scientific Reports 13, no. 1 (2023): -.
Harvard	Mahdikia H et al. (2023) 'Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo', Scientific Reports, 13(1), pp. -.
Vancouver	Mahdikia H, Saadati F, Alizadeh AM, Khalighfard S, Bekeschus S, Shokri B. Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo. Scientific Reports. 2023;13(1):-.
BibTex	@article{ author = {Mahdikia H and Saadati F and Alizadeh AM and Khalighfard S and Bekeschus S and Shokri B}, title = {Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo}, journal = {Scientific Reports}, volume = {13}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Mahdikia H AU - Saadati F AU - Alizadeh AM AU - Khalighfard S AU - Bekeschus S AU - Shokri B TI - Low-Frequency Magnetic Fields Potentiate Plasma-Modified Magneto-Electric Nanoparticle Drug Loading for Anticancer Activity in Vitro and in Vivo JO - Scientific Reports VL - 13 IS - 1 SP - EP - PY - 2023 ER -

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