Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application

Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application Publisher

Eivazzadehkeihan R¹ ; Choopani L² ; Aghamirza Moghim Aliabadi H^{3, 4} ; Ganjali F² ; Kashtiaray A² ; Maleki A² ; Ahangari Cohan R¹ ; Salimi Bani M⁵ ; Komijani S^{6, 7} ; Ahadian MM⁸ ; Salehpour N⁹ ; Mahdavi M¹⁰

Show Affiliations

1. Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran
2. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
3. Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
4. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
5. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
6. Biotechnology Research Center, Pasteur Institute of Iran, No.358, 12 Farvardin St., Tehran, 1316943551, Iran
7. Department of Biotechnology School of Biology, Alzahra University, Tehran, Iran
8. Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran
9. Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran
10. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Materials Chemistry and Physics Published:2022

Abstract

A novel and high potent magnetic nanobiocomposite was prepared based on Carboxymethyl cellulose (CMC) and epichlorohydrin (ECH) cross-linker interactions to form a three-dimensional cross-linked CMC hydrogel followed by silk fibroin (SF) and halloysite nanotubes (HNTs) modifications and further in situ Fe3O4 magnetic nanoparticles (MNPs) formation. Different analytical techniques like FT-IR, EDX, FE-SEM, XRD, TGA, and VSM were used to characterize the structure of the prepared nanobiocomposite. The spherical morphology of Fe3O4 MNPs and tubular HNTs were presented in the FE-SEM images. In biological tests, since the hemolysis percent was even less than the negative control, the CMC hydrogel/SF/HNTs/Fe3O4 nanobiocomposite was fully hemocompatible. This nanobiocomposite was non-toxic toward HEK293T normal cell line. In addition, the proliferation rate and viability percentage reduction of BT549 cancer cells confirmed the anticancer property of the nanobiocomposite against breast cancer cell lines. This magnetic nanocomposite was applied in hyperthermia cancer therapy, and the maximum specific absorption rate (SAR, 67 W/g) was obtained at the concentration of 1 mg/mL under the magnetic frequency of 400 kHz. © 2022 Elsevier B.V.

Style	Citing Format
MLA	Eivazzadehkeihan R, et al.. "Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application." Materials Chemistry and Physics, vol. 287, no. , 2022, pp. -.
APA	Eivazzadehkeihan R, Choopani L, Aghamirza Moghim Aliabadi H, Ganjali F, Kashtiaray A, Maleki A, Ahangari Cohan R, Salimi Bani M, Komijani S, Ahadian MM, Salehpour N, Mahdavi M (2022). Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application. Materials Chemistry and Physics, 287(), -.
Chicago	Eivazzadehkeihan R, Choopani L, Aghamirza Moghim Aliabadi H, Ganjali F, Kashtiaray A, Maleki A, Ahangari Cohan R, et al.. "Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application." Materials Chemistry and Physics 287, no. (2022): -.
Harvard	Eivazzadehkeihan R et al. (2022) 'Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application', Materials Chemistry and Physics, 287(), pp. -.
Vancouver	Eivazzadehkeihan R, Choopani L, Aghamirza Moghim Aliabadi H, Ganjali F, Kashtiaray A, Maleki A, et al.. Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application. Materials Chemistry and Physics. 2022;287():-.
BibTex	@article{ author = {Eivazzadehkeihan R and Choopani L and Aghamirza Moghim Aliabadi H and Ganjali F and Kashtiaray A and Maleki A and Ahangari Cohan R and Salimi Bani M and Komijani S and Ahadian MM and Salehpour N and Mahdavi M}, title = {Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application}, journal = {Materials Chemistry and Physics}, volume = {287}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Eivazzadehkeihan R AU - Choopani L AU - Aghamirza Moghim Aliabadi H AU - Ganjali F AU - Kashtiaray A AU - Maleki A AU - Ahangari Cohan R AU - Salimi Bani M AU - Komijani S AU - Ahadian MM AU - Salehpour N AU - Mahdavi M TI - Magnetic Carboxymethyl Cellulose/Silk Fibroin Hydrogel Embedded With Halloysite Nanotubes As a Biocompatible Nanobiocomposite With Hyperthermia Application JO - Materials Chemistry and Physics VL - 287 IS - SP - EP - PY - 2022 ER -

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