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Global Prevalence and Incidence of Young Onset Parkinson's Disease: A Systematic Review and Meta-Analysis Publisher



Nabizadeh F1 ; Seyedmirzaei H2, 3 ; Rafiei N4 ; Maryam Vafaei S5 ; Shekouh D6 ; Mehrtabar E2 ; Mirzaaghazadeh E7 ; Mirzaasgari Z8
Authors
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Authors Affiliations
  1. 1. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Science, Tehran, Iran
  3. 3. Interdisciplinary Neuroscience Research Program (INRP), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. School of Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
  6. 6. Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Faculty of Medicine, Tabriz university of medical sciences, Tabriz, Iran
  8. 8. Department of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Clinical Neuroscience Published:2024


Abstract

Background: There is a lack of enough evidence regarding the epidemiology of Young-onset Parkinson's disease (YOPD) which is needed by clinicians and healthcare policymakers. Aim: Herein, in this systematic review and meta-analysis, we aimed to estimate the global prevalence and incidence rates of YOPD. Methods: We searched the literature in PubMed, Scopus, and Web of Science in May 2022. We included retrospective, prospective, cross-sectional observational population-based studies that reported the prevalence or incidence of PD in individuals younger than 40 years with known diagnostic criteria. Results: After two-step screening, 50 studies were eligible to be included in our study. The age-standardized prevalence of YOPD was 10.2 per 100,000 persons globally while it was 14.7 per 100,000 population in European countries. Age-standardized prevalence estimates for 5-year age bands showed that the YOPD prevalence estimates varied from 6.1 per 100,000 population in the group aged 20–24 to 16.1 per 100,000 population in the group aged 35–39. Also, the age-standardized incidence of YOPD was 1.3 per 100,000 person-years population worldwide and 1.2 per 100,000 person-years in the European population. Conclusion: Based on this systematic review and meta-analysis, the overall prevalence of YOPD is 10.2 per 100,000 population, although estimates of the prevalence and incidence in low-income countries remain scarce. To improve monitoring and certain diagnoses of YOPD, healthcare providers and policymakers should be aware that much more effective tools are required. © 2024 Elsevier Ltd
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