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Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016 Publisher Pubmed



Ray Dorsey E1 ; Elbaz A2 ; Nichols E3 ; Abdallah F4 ; Abdelalim A4 ; Adsuar JC5 ; Ansha MG7 ; Brayne C8 ; Choi JYJ9 ; Colladomateo D6, 10 ; Dahodwala N11 ; Do HP12 ; Edessa D13 ; Endres M15 Show All Authors
Authors
  1. Ray Dorsey E1
  2. Elbaz A2
  3. Nichols E3
  4. Abdallah F4
  5. Abdelalim A4
  6. Adsuar JC5
  7. Ansha MG7
  8. Brayne C8
  9. Choi JYJ9
  10. Colladomateo D6, 10
  11. Dahodwala N11
  12. Do HP12
  13. Edessa D13
  14. Endres M15
  15. Fereshtehnejad SM16, 17
  16. Foreman KJ3, 18
  17. Gankpe FG19, 20
  18. Gupta R21, 22
  19. Hankey GJ23
  20. Hay SI3
  21. Hegazy MI4
  22. Hibstu DT24
  23. Kasaeian A25
  24. Khader Y26
  25. Khalil I3
  26. Khang YH27
  27. Kim YJ28
  28. Kokubo Y29
  29. Logroscino G30
  30. Massano J31
  31. Ibrahim NM33
  32. Mohammed MA34, 35
  33. Mohammadi A36
  34. Moradilakeh M37
  35. Naghavi M3
  36. Nguyen BT12
  37. Nirayo YL38
  38. Ogbo FA39
  39. Owolabi MO40
  40. Pereira DM32
  41. Postma MJ41
  42. Qorbani M42
  43. Rahman MA43, 44
  44. Roba KT14
  45. Safari H45
  46. Safiri S46
  47. Satpathy M47
  48. Sawhney M48
  49. Shafieesabet A49
  50. Shiferaw MS13
  51. Smith M3
  52. Szoeke CEI50
  53. Tabaresseisdedos R52
  54. Truong NT12
  55. Ukwaja KN53
  56. Venketasubramanian N54, 55
  57. Villafaina S5
  58. Weldegwergs KG38
  59. Westerman R56
  60. Wijeratne T51, 57
  61. Winkler AS58, 59
  62. Xuan BT60
  63. Yonemoto N61
  64. Feigin VL62
  65. Vos T3
  66. Murray CJL3
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurology, University of Rochester, United States
  2. 2. INSERM U1018-CESP, Hopital Paul Brousse, Villejuif cedex, France
  3. 3. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States
  4. 4. Department of Neurology, Cairo University, Cairo, Egypt
  5. 5. Faculty of Sport Science, University of Extremadura, Spain
  6. 6. Departamento de Didactica de la Expresion Musical, Plastica y Corporal, University of Extremadura, Spain
  7. 7. Public Health, Debre Berhan University, Debre Berhan, Ethiopia
  8. 8. Public Health and Primary Care, University of Cambridge, United Kingdom
  9. 9. Biochemistry, Biomedical Science, Seoul National University Hospital, Seoul, South Korea
  10. 10. Facultad de Educacion Universidad Autonoma de Chile, Talca, Chile
  11. 11. Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States
  12. 12. Institute for Global Health Innovations, Duy Tan University, Hanoi, Viet Nam
  13. 13. School of Pharmacy, Haramaya University, Harar, Ethiopia
  14. 14. School of Nursing and Midwifery, Haramaya University, Harar, Ethiopia
  15. 15. Department of Neurology, Charite-Universitatsmedizin Berlin, Berlin, Germany
  16. 16. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
  17. 17. Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
  18. 18. Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom
  19. 19. Neurosurgery Department, Faculty of Medicine and Pharmacy of Fez, Fez, Morocco
  20. 20. Non-Communicable Disease Department, Laboratoire D’etudes et de Recherche-action en Sante (leras Afrique), Porto Novo, Benin
  21. 21. West Virginia Bureau for Public Health, Charleston, WV, United States
  22. 22. Health Policy, Management and Leadership, West Virginia University School of Public Health, Morgantown, WV, United States
  23. 23. Medical School, University of Western Australia, Perth, WA, Australia
  24. 24. Department of Reproductive Health, Hawassa University, Hawassa, Ethiopia
  25. 25. Hematology-oncology and Stem Cell Transplantation Research Center, Hematologic Malignancies Research Center, Tehran University of Medical Sciences, Tehran, Iran
  26. 26. Public Health and Community Medicine, Jordan University of Science and Technology, Alramtha, Jordan
  27. 27. Department of Health Policy and Management, College of Medicine, Institute of Health Policy and Management, SNU Medical Research Center, Seoul National University, Seoul, South Korea
  28. 28. School of Medicine, Xiamen University Malaysia, Sepang, Malaysia
  29. 29. Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
  30. 30. University of Bari Aldo Moro, Bari, Italy
  31. 31. Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal
  32. 32. REQUIMTE/LAQV, Laboratorio de Farmacognosia, Departamento de Quimica, Faculdade de Farmacia, University of Porto, Porto, Portugal
  33. 33. Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Bandar Tun Razak, Malaysia
  34. 34. Department of Public Health, Jigjiga Unviersity, Jigjiga, Ethiopia
  35. 35. University of Sydney, Sydney, NSW, Australia
  36. 36. Neuroscience Research Center, Baqiyatallah University of Medical Science, Tehran, Iran
  37. 37. Community and Family Medicine, Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran
  38. 38. Department of Clinical Pharmacy, Mekelle University, Mekelle, Ethiopia
  39. 39. Western Sydney University, Penrith, NSW, Australia
  40. 40. Department of Medicine, University of Ibadan, Ibadan, Nigeria
  41. 41. Department of Pharmacy, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
  42. 42. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  43. 43. Austin Clinical School of Nursing, La Trobe University, Heidelberg, VIC, Australia
  44. 44. School of Medicine, Deakin University, Waurn Ponds, VIC, Australia
  45. 45. Department of Neurosurgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  46. 46. Department of Public Health, Managerial Epidemiology Research Center, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran
  47. 47. Centre of Advanced Study in Psychology, Utkal University, Bhubaneswar, India
  48. 48. Department of Public Health Sciences, University of North Carolina at Charlotte, Charlotte, NC, United States
  49. 49. Langone Medical Center, New York University, New York, NY, United States
  50. 50. Department of Medicine, Dentistry and Health Science, University of Melbourne, Melbourne, VIC, Australia
  51. 51. Department of Medicine, University of Melbourne, Melbourne, VIC, Australia
  52. 52. Department of Medicine, University of Valencia, Valencia, Spain
  53. 53. Department of Internal Medicine, Federal Teaching Hospital, Abakaliki, Nigeria
  54. 54. Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore
  55. 55. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  56. 56. Competence Center of Mortality-follow-up, German National Cohort, Federal Institute for Population Research, Wiesbaden, Germany
  57. 57. Department of Psychology, La Trobe University, Melbourne, Australia
  58. 58. Department of Neurology, Technical University of Munich, Munich, Germany
  59. 59. Institute for Health and Society, University of Oslo, Oslo, Norway
  60. 60. Department of Health Economics, Hanoi Medical University, Hanoi, Viet Nam
  61. 61. Department of Biostatistics, School of Public Health, Kyoto University, Kyoto, Japan
  62. 62. National Institute for Stroke and Applied Neurosciences, Auckland University of Technology, Auckland, New Zealand

Source: The Lancet Neurology Published:2018


Abstract

Background: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. Methods: Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. Findings: In 2016, 6·1 million (95% uncertainty interval [UI] 5·0–7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0–3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1–25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2–79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6–4·0) DALYs and 211 296 deaths (95% UI 167 771–265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36–1·43) and 1990 (1·37, 1·34–1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. Interpretation: Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. Funding: Bill & Melinda Gates Foundation. © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
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