Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016

Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016 Publisher Pubmed

Ray Dorsey E¹ ; Elbaz A² ; Nichols E³ ; Abdallah F⁴ ; Abdelalim A⁴ ; Adsuar JC⁵ ; Ansha MG⁷ ; Brayne C⁸ ; Choi JYJ⁹ ; Colladomateo D^{6, 10} ; Dahodwala N¹¹ ; Do HP¹² ; Edessa D¹³ ; Endres M¹⁵ Show All Authors

Ray Dorsey E¹
Elbaz A²
Nichols E³
Abdallah F⁴
Abdelalim A⁴
Adsuar JC⁵
Ansha MG⁷
Brayne C⁸
Choi JYJ⁹
Colladomateo D^{6, 10}
Dahodwala N¹¹
Do HP¹²
Edessa D¹³
Endres M¹⁵
Fereshtehnejad SM^{16, 17}
Foreman KJ^{3, 18}
Gankpe FG^{19, 20}
Gupta R^{21, 22}
Hankey GJ²³
Hay SI³
Hegazy MI⁴
Hibstu DT²⁴
Kasaeian A²⁵
Khader Y²⁶
Khalil I³
Khang YH²⁷
Kim YJ²⁸
Kokubo Y²⁹
Logroscino G³⁰
Massano J³¹
Ibrahim NM³³
Mohammed MA^{34, 35}
Mohammadi A³⁶
Moradilakeh M³⁷
Naghavi M³
Nguyen BT¹²
Nirayo YL³⁸
Ogbo FA³⁹
Owolabi MO⁴⁰
Pereira DM³²
Postma MJ⁴¹
Qorbani M⁴²
Rahman MA^{43, 44}
Roba KT¹⁴
Safari H⁴⁵
Safiri S⁴⁶
Satpathy M⁴⁷
Sawhney M⁴⁸
Shafieesabet A⁴⁹
Shiferaw MS¹³
Smith M³
Szoeke CEI⁵⁰
Tabaresseisdedos R⁵²
Truong NT¹²
Ukwaja KN⁵³
Venketasubramanian N^{54, 55}
Villafaina S⁵
Weldegwergs KG³⁸
Westerman R⁵⁶
Wijeratne T^{51, 57}
Winkler AS^{58, 59}
Xuan BT⁶⁰
Yonemoto N⁶¹
Feigin VL⁶²
Vos T³
Murray CJL³

Source: The Lancet Neurology Published:2018

Abstract

Background: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. Methods: Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. Findings: In 2016, 6·1 million (95% uncertainty interval [UI] 5·0–7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0–3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1–25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2–79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6–4·0) DALYs and 211 296 deaths (95% UI 167 771–265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36–1·43) and 1990 (1·37, 1·34–1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. Interpretation: Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. Funding: Bill & Melinda Gates Foundation. © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

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Style	Citing Format
MLA	Ray Dorsey E, et al.. "Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016." The Lancet Neurology, vol. 17, no. 11, 2018, pp. 939-953.
APA	Ray Dorsey E, Elbaz A, Nichols E, Abdallah F, Abdelalim A, Adsuar JC, Ansha MG, Brayne C, Choi JYJ, Colladomateo D, Dahodwala N, Do HP, Edessa D, Endres M, Fereshtehnejad SM, Foreman KJ, Gankpe FG, Gupta R, Hankey GJ, ... Murray CJL (2018). Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 17(11), 939-953.
Chicago	Ray Dorsey E, Elbaz A, Nichols E, Abdallah F, Abdelalim A, Adsuar JC, Ansha MG, et al.. "Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016." The Lancet Neurology 17, no. 11 (2018): 939-953.
Harvard	Ray Dorsey E et al. (2018) 'Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016', The Lancet Neurology, 17(11), pp. 939-953.
Vancouver	Ray Dorsey E, Elbaz A, Nichols E, Abdallah F, Abdelalim A, Adsuar JC, et al.. Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016. The Lancet Neurology. 2018;17(11):939-953.
BibTex	@article{ author = {Ray Dorsey E and Elbaz A and Nichols E and Abdallah F and Abdelalim A and Adsuar JC and Ansha MG and Brayne C and Choi JYJ and Colladomateo D and Dahodwala N and Do HP and Edessa D and Endres M and Fereshtehnejad SM and Foreman KJ and Gankpe FG and Gupta R and Hankey GJ and Hay SI and Hegazy MI and Hibstu DT and Kasaeian A and Khader Y and Khalil I and Khang YH and Kim YJ and Kokubo Y and Logroscino G and Massano J and Ibrahim NM and Mohammed MA and Mohammadi A and Moradilakeh M and Naghavi M and Nguyen BT and Nirayo YL and Ogbo FA and Owolabi MO and Pereira DM and Postma MJ and Qorbani M and Rahman MA and Roba KT and Safari H and Safiri S and Satpathy M and Sawhney M and Shafieesabet A and Shiferaw MS and Smith M and Szoeke CEI and Tabaresseisdedos R and Truong NT and Ukwaja KN and Venketasubramanian N and Villafaina S and Weldegwergs KG and Westerman R and Wijeratne T and Winkler AS and Xuan BT and Yonemoto N and Feigin VL and Vos T and Murray CJL}, title = {Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016}, journal = {The Lancet Neurology}, volume = {17}, number = {11}, pages = {939-953}, year = {2018} }
RIS	TY - JOUR AU - Ray Dorsey E AU - Elbaz A AU - Nichols E AU - Abdallah F AU - Abdelalim A AU - Adsuar JC AU - Ansha MG AU - Brayne C AU - Choi JYJ AU - Colladomateo D AU - Dahodwala N AU - Do HP AU - Edessa D AU - Endres M AU - Fereshtehnejad SM AU - Foreman KJ AU - Gankpe FG AU - Gupta R AU - Hankey GJ AU - Hay SI AU - Hegazy MI AU - Hibstu DT AU - Kasaeian A AU - Khader Y AU - Khalil I AU - Khang YH AU - Kim YJ AU - Kokubo Y AU - Logroscino G AU - Massano J AU - Ibrahim NM AU - Mohammed MA AU - Mohammadi A AU - Moradilakeh M AU - Naghavi M AU - Nguyen BT AU - Nirayo YL AU - Ogbo FA AU - Owolabi MO AU - Pereira DM AU - Postma MJ AU - Qorbani M AU - Rahman MA AU - Roba KT AU - Safari H AU - Safiri S AU - Satpathy M AU - Sawhney M AU - Shafieesabet A AU - Shiferaw MS AU - Smith M AU - Szoeke CEI AU - Tabaresseisdedos R AU - Truong NT AU - Ukwaja KN AU - Venketasubramanian N AU - Villafaina S AU - Weldegwergs KG AU - Westerman R AU - Wijeratne T AU - Winkler AS AU - Xuan BT AU - Yonemoto N AU - Feigin VL AU - Vos T AU - Murray CJL TI - Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016 JO - The Lancet Neurology VL - 17 IS - 11 SP - 939 EP - 953 PY - 2018 ER -

Style

Citing Format

MLA

Ray Dorsey E, et al.. "Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016." The Lancet Neurology, vol. 17, no. 11, 2018, pp. 939-953.

APA

Ray Dorsey E, Elbaz A, Nichols E, Abdallah F, Abdelalim A, Adsuar JC, Ansha MG, Brayne C, Choi JYJ, Colladomateo D, Dahodwala N, Do HP, Edessa D, Endres M, Fereshtehnejad SM, Foreman KJ, Gankpe FG, Gupta R, Hankey GJ, ... Murray CJL (2018). Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 17(11), 939-953.

Chicago

Ray Dorsey E, Elbaz A, Nichols E, Abdallah F, Abdelalim A, Adsuar JC, Ansha MG, et al.. "Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016." The Lancet Neurology 17, no. 11 (2018): 939-953.

Harvard

Ray Dorsey E et al. (2018) 'Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016', The Lancet Neurology, 17(11), pp. 939-953.

Vancouver

Ray Dorsey E, Elbaz A, Nichols E, Abdallah F, Abdelalim A, Adsuar JC, et al.. Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016. The Lancet Neurology. 2018;17(11):939-953.

BibTex

@article{ author = {Ray Dorsey E and Elbaz A and Nichols E and Abdallah F and Abdelalim A and Adsuar JC and Ansha MG and Brayne C and Choi JYJ and Colladomateo D and Dahodwala N and Do HP and Edessa D and Endres M and Fereshtehnejad SM and Foreman KJ and Gankpe FG and Gupta R and Hankey GJ and Hay SI and Hegazy MI and Hibstu DT and Kasaeian A and Khader Y and Khalil I and Khang YH and Kim YJ and Kokubo Y and Logroscino G and Massano J and Ibrahim NM and Mohammed MA and Mohammadi A and Moradilakeh M and Naghavi M and Nguyen BT and Nirayo YL and Ogbo FA and Owolabi MO and Pereira DM and Postma MJ and Qorbani M and Rahman MA and Roba KT and Safari H and Safiri S and Satpathy M and Sawhney M and Shafieesabet A and Shiferaw MS and Smith M and Szoeke CEI and Tabaresseisdedos R and Truong NT and Ukwaja KN and Venketasubramanian N and Villafaina S and Weldegwergs KG and Westerman R and Wijeratne T and Winkler AS and Xuan BT and Yonemoto N and Feigin VL and Vos T and Murray CJL}, title = {Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016}, journal = {The Lancet Neurology}, volume = {17}, number = {11}, pages = {939-953}, year = {2018} }

RIS

TY - JOUR
AU - Ray Dorsey E
AU - Elbaz A
AU - Nichols E
AU - Abdallah F
AU - Abdelalim A
AU - Adsuar JC
AU - Ansha MG
AU - Brayne C
AU - Choi JYJ
AU - Colladomateo D
AU - Dahodwala N
AU - Do HP
AU - Edessa D
AU - Endres M
AU - Fereshtehnejad SM
AU - Foreman KJ
AU - Gankpe FG
AU - Gupta R
AU - Hankey GJ
AU - Hay SI
AU - Hegazy MI
AU - Hibstu DT
AU - Kasaeian A
AU - Khader Y
AU - Khalil I
AU - Khang YH
AU - Kim YJ
AU - Kokubo Y
AU - Logroscino G
AU - Massano J
AU - Ibrahim NM
AU - Mohammed MA
AU - Mohammadi A
AU - Moradilakeh M
AU - Naghavi M
AU - Nguyen BT
AU - Nirayo YL
AU - Ogbo FA
AU - Owolabi MO
AU - Pereira DM
AU - Postma MJ
AU - Qorbani M
AU - Rahman MA
AU - Roba KT
AU - Safari H
AU - Safiri S
AU - Satpathy M
AU - Sawhney M
AU - Shafieesabet A
AU - Shiferaw MS
AU - Smith M
AU - Szoeke CEI
AU - Tabaresseisdedos R
AU - Truong NT
AU - Ukwaja KN
AU - Venketasubramanian N
AU - Villafaina S
AU - Weldegwergs KG
AU - Westerman R
AU - Wijeratne T
AU - Winkler AS
AU - Xuan BT
AU - Yonemoto N
AU - Feigin VL
AU - Vos T
AU - Murray CJL
TI - Global, Regional, and National Burden of Parkinson's Disease, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016
JO - The Lancet Neurology
VL - 17
IS - 11
SP - 939
EP - 953
PY - 2018
ER -

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